| pubmed-article:16569215 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16569215 | lifeskim:mentions | umls-concept:C0174680 | lld:lifeskim |
| pubmed-article:16569215 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:16569215 | lifeskim:mentions | umls-concept:C0019643 | lld:lifeskim |
| pubmed-article:16569215 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:16569215 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:16569215 | lifeskim:mentions | umls-concept:C1417683 | lld:lifeskim |
| pubmed-article:16569215 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
| pubmed-article:16569215 | lifeskim:mentions | umls-concept:C1416457 | lld:lifeskim |
| pubmed-article:16569215 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16569215 | pubmed:dateCreated | 2006-6-9 | lld:pubmed |
| pubmed-article:16569215 | pubmed:abstractText | INSM1/IA-1 (insulinoma-associated 1) is a developmentally regulated zinc-finger transcription factor, exclusively expressed in the foetal pancreas and nervous system, and in tumours of neuroendocrine origin. We have identified an INSM1 binding site in the neuroD/beta2 promoter and demonstrated transcriptional repressor activity of INSM1 by transient transfection assay. A chromatin immunoprecipitation assay confirmed that in vivo INSM1 is situated on the promoter region of the neuroD/beta2 gene. In an attempt to elucidate the molecular mechanism of transcriptional repression by the INSM1 gene, cyclin D1 was identified as an interacting protein by using a 45-day-old human foetal brain cDNA library and a yeast two-hybrid screen. The physical association between INSM1 and cyclin D1 was confirmed by in vitro and in vivo pull-down assay. Cyclin D1 co-operates with INSM1 and suppresses neuroD/beta2 promoter activity. Co-immunoprecipitation of INSM1, cyclin D1 and HDACs (histone deacetylases) in mammalian cells revealed that INSM1 interacts with HDAC-1 and -3 and that this interaction is mediated through cyclin D1. Overexpression of cyclin D1 and HDAC-3 significantly enhanced the transcriptional repression activity of INSM1 on the neuroD/beta2 promoter. A further chromatin immunoprecipitation assay confirmed that HDAC-3 occupies this same region of the neuroD/beta2 promoter, by forming a transcription complex with INSM1. Thus we conclude that INSM1 recruits cyclin D1 and HDACs, which confer transcriptional repressor activity. | lld:pubmed |
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| pubmed-article:16569215 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16569215 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16569215 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16569215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16569215 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16569215 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16569215 | pubmed:issn | 1470-8728 | lld:pubmed |
| pubmed-article:16569215 | pubmed:author | pubmed-author:BreslinMary... | lld:pubmed |
| pubmed-article:16569215 | pubmed:author | pubmed-author:LanMichael... | lld:pubmed |
| pubmed-article:16569215 | pubmed:author | pubmed-author:WangHong-WeiH... | lld:pubmed |
| pubmed-article:16569215 | pubmed:author | pubmed-author:LiuWei-DongWD | lld:pubmed |
| pubmed-article:16569215 | pubmed:author | pubmed-author:MuguiraMichel... | lld:pubmed |
| pubmed-article:16569215 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16569215 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16569215 | pubmed:volume | 397 | lld:pubmed |
| pubmed-article:16569215 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16569215 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16569215 | pubmed:pagination | 169-77 | lld:pubmed |
| pubmed-article:16569215 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16569215 | pubmed:year | 2006 | lld:pubmed |
