| pubmed-article:16568152 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16568152 | lifeskim:mentions | umls-concept:C0003075 | lld:lifeskim |
| pubmed-article:16568152 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:16568152 | lifeskim:mentions | umls-concept:C0025552 | lld:lifeskim |
| pubmed-article:16568152 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:16568152 | lifeskim:mentions | umls-concept:C1305923 | lld:lifeskim |
| pubmed-article:16568152 | lifeskim:mentions | umls-concept:C0178812 | lld:lifeskim |
| pubmed-article:16568152 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:16568152 | lifeskim:mentions | umls-concept:C2911648 | lld:lifeskim |
| pubmed-article:16568152 | lifeskim:mentions | umls-concept:C1719797 | lld:lifeskim |
| pubmed-article:16568152 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:16568152 | pubmed:dateCreated | 2006-7-14 | lld:pubmed |
| pubmed-article:16568152 | pubmed:abstractText | Gas-phase reactions of multiply protonated polypeptides and metal containing anions represent a new methodology for manipulating the cationizing agent composition of polypeptides. This approach affords greater flexibility in forming metal containing ions than commonly used methods, such as electrospray ionization of a metal salt/peptide mixture and matrix-assisted laser desorption. Here, the effects of properties of the polypeptide and anionic reactant on the nature of the reaction products are investigated. For a given metal, the identity of the ligand in the metal containing anion is the dominant factor in determining product distributions. For a given polypeptide ion, the difference between the metal ion affinity and the proton affinity of the negatively charged ligand in the anionic reactant is of predictive value in anticipating the relative contributions of proton transfer and metal ion transfer. Furthermore, the binding strength of the ligand anion to charge sites in the polypeptide correlates with the extent of observed cluster ion formation. Polypeptide composition, sequence, and charge state can also play a notable role in determining the distribution of products. In addition to their usefulness in gas-phase ion synthesis strategies, the reactions of protonated polypeptides and metal containing anions represent an example of a gas-phase ion/ion reaction that is sensitive to polypeptide structure. These observations are noteworthy in that they allude to the possibility of obtaining information, without requiring fragmentation of the peptide backbone, about ion structure as well as the relative ion affinities associated with the reactants. | lld:pubmed |
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| pubmed-article:16568152 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16568152 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16568152 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16568152 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16568152 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16568152 | pubmed:issn | 1089-5639 | lld:pubmed |
| pubmed-article:16568152 | pubmed:author | pubmed-author:McLuckeyScott... | lld:pubmed |
| pubmed-article:16568152 | pubmed:author | pubmed-author:NewtonKelly... | lld:pubmed |
| pubmed-article:16568152 | pubmed:author | pubmed-author:AmunugamaRavi... | lld:pubmed |
| pubmed-article:16568152 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16568152 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:16568152 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:16568152 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16568152 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16568152 | pubmed:pagination | 3608-16 | lld:pubmed |
| pubmed-article:16568152 | pubmed:dateRevised | 2011-1-4 | lld:pubmed |
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| pubmed-article:16568152 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16568152 | pubmed:articleTitle | Gas-phase ion/ion reactions of multiply protonated polypeptides with metal containing anions. | lld:pubmed |
| pubmed-article:16568152 | pubmed:affiliation | Department of Chemistry, Purdue University, West Lafayette, IN 47907-2084, USA. | lld:pubmed |
| pubmed-article:16568152 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16568152 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:16568152 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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