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pubmed-article:16564292pubmed:abstractTextContact of blood with the artificial surfaces of the cardiopulmonary bypass (CPB) system is considered to be a main cause of complement activation. Improving the biocompatibility of the system by reduction of contact activation of blood elements and thereby producing less inflammatory response is evidently desired, especially for neonates and infants who are more susceptible to the deleterious effects of CPB. A phosphorylcholine coating, Phisio, is designed to mimic the natural interfaces of blood. The aim of this study is to compare the influence of a phosphorylcholine-coated CPB system versus an uncoated CPB system on complement activation and clinical outcomes.lld:pubmed
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pubmed-article:16564292pubmed:authorpubmed-author:DraaismaAnjo...lld:pubmed
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pubmed-article:16564292pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16564292pubmed:year2006lld:pubmed
pubmed-article:16564292pubmed:articleTitlePhosphorylcholine coating of bypass systems used for young infants does not attenuate the inflammatory response.lld:pubmed
pubmed-article:16564292pubmed:affiliationDepartment of Extra Corporeal Circulation, Leiden University Medical Center, Leiden, The Netherlands. a.m.draaisma@lumc.nllld:pubmed
pubmed-article:16564292pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16564292pubmed:publicationTypeRandomized Controlled Triallld:pubmed
pubmed-article:16564292pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed