| pubmed-article:16563355 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16563355 | lifeskim:mentions | umls-concept:C0009333 | lld:lifeskim |
| pubmed-article:16563355 | lifeskim:mentions | umls-concept:C0009325 | lld:lifeskim |
| pubmed-article:16563355 | lifeskim:mentions | umls-concept:C0171955 | lld:lifeskim |
| pubmed-article:16563355 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:16563355 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:16563355 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:16563355 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:16563355 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:16563355 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16563355 | pubmed:dateCreated | 2006-4-5 | lld:pubmed |
| pubmed-article:16563355 | pubmed:abstractText | Anchoring functions of collagen VII depend on its ability to form homotypic fibrils and to bind to other macromolecules to form heterotypic complexes. Biosensor-based binding assays were employed to analyze the kinetics of the NC1 domain-mediated binding of collagen VII to laminin 5, collagen IV, and collagen I. We showed that collagen VII interacts with laminin 5 and collagen IV with a Kd value of 10(-9) M. In contrast, the NC1-mediated binding to collagen I was weak with a Kd value of 10(-6) M. Binding assays also showed that the NC1 domain utilizes the same region to bind to both laminin 5 and collagen IV. We postulate that the ability of the NC1 domains to bind with high affinities to laminin 5 and collagen IV facilitates stabilization of the structure of the basement membrane itself and that the NC1-collagen I interaction may be less important for stabilization of the dermal-epidermal junction. | lld:pubmed |
| pubmed-article:16563355 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16563355 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16563355 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16563355 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16563355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16563355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16563355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16563355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16563355 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16563355 | pubmed:month | May | lld:pubmed |
| pubmed-article:16563355 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:16563355 | pubmed:author | pubmed-author:FertalaAndrze... | lld:pubmed |
| pubmed-article:16563355 | pubmed:author | pubmed-author:UittoJouniJ | lld:pubmed |
| pubmed-article:16563355 | pubmed:author | pubmed-author:BrittinghamRa... | lld:pubmed |
| pubmed-article:16563355 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16563355 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:16563355 | pubmed:volume | 343 | lld:pubmed |
| pubmed-article:16563355 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16563355 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16563355 | pubmed:pagination | 692-9 | lld:pubmed |
| pubmed-article:16563355 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16563355 | pubmed:meshHeading | pubmed-meshheading:16563355... | lld:pubmed |
| pubmed-article:16563355 | pubmed:meshHeading | pubmed-meshheading:16563355... | lld:pubmed |
| pubmed-article:16563355 | pubmed:meshHeading | pubmed-meshheading:16563355... | lld:pubmed |
| pubmed-article:16563355 | pubmed:meshHeading | pubmed-meshheading:16563355... | lld:pubmed |
| pubmed-article:16563355 | pubmed:meshHeading | pubmed-meshheading:16563355... | lld:pubmed |
| pubmed-article:16563355 | pubmed:meshHeading | pubmed-meshheading:16563355... | lld:pubmed |
| pubmed-article:16563355 | pubmed:meshHeading | pubmed-meshheading:16563355... | lld:pubmed |
| pubmed-article:16563355 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16563355 | pubmed:articleTitle | High-affinity binding of the NC1 domain of collagen VII to laminin 5 and collagen IV. | lld:pubmed |
| pubmed-article:16563355 | pubmed:affiliation | Department of Dermatology and Cutaneous Biology, Jefferson Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA. | lld:pubmed |
| pubmed-article:16563355 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16563355 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16563355 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16563355 | lld:pubmed |
