| pubmed-article:1655638 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1655638 | lifeskim:mentions | umls-concept:C0684336 | lld:lifeskim |
| pubmed-article:1655638 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1655638 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:1655638 | lifeskim:mentions | umls-concept:C0042890 | lld:lifeskim |
| pubmed-article:1655638 | lifeskim:mentions | umls-concept:C1327413 | lld:lifeskim |
| pubmed-article:1655638 | lifeskim:mentions | umls-concept:C0204695 | lld:lifeskim |
| pubmed-article:1655638 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1655638 | pubmed:dateCreated | 1991-10-30 | lld:pubmed |
| pubmed-article:1655638 | pubmed:abstractText | C57Bl/6 female mice fed a Vitamin D (VIT-D)-deficient diet had serum levels of 25-hydroxyvitamin D decreasing with the time of diet exposure (3 and 8 weeks). Cytokine production (IL-6, TNF and IL-1) by peritoneal macrophages cultured in vitro with a standard stimulus, LPS, evaluated in the supernatants as biological activity, was significantly reduced in VIT-D-deficient animals. The defect in monokine production was partial and was evident at suboptimal LPS concentrations and incubation times. I-A antigen expression, induced in macrophages by in vitro exposure to IFN-gamma, was not modified in VIT-D-deficient mice, but IFN-gamma-inducible macrophage cytotoxicity to tumour target cells was significantly decreased in VIT-D-deficient animals. Moreover, basal and Poly I:C-induced NK activity was not modified by VIT-D deficiency. Thus, macrophage functions, such as cytokine production and tumour cytotoxicity induction, are down-modulated in vitro by VIT-D deprivation. To give more support to the relevance of VIT-D availability for cytokine production, TNF and IL-6 have been evaluated in the sera of control and VIT-D-deficient mice given LPS as a model stimulus. Serum peak levels of both cytokines were at least halved in VIT-D-deprived mice. Thus, VIT-D deficiency may represent a model of partial defect of monokine production. | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1655638 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1655638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1655638 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1655638 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1655638 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:1655638 | pubmed:author | pubmed-author:VecchiAA | lld:pubmed |
| pubmed-article:1655638 | pubmed:author | pubmed-author:MantovaniAA | lld:pubmed |
| pubmed-article:1655638 | pubmed:author | pubmed-author:SironiMM | lld:pubmed |
| pubmed-article:1655638 | pubmed:author | pubmed-author:LuiniWW | lld:pubmed |
| pubmed-article:1655638 | pubmed:author | pubmed-author:PedrazzoniMM | lld:pubmed |
| pubmed-article:1655638 | pubmed:author | pubmed-author:BottazziBB | lld:pubmed |
| pubmed-article:1655638 | pubmed:author | pubmed-author:RigantiFF | lld:pubmed |
| pubmed-article:1655638 | pubmed:author | pubmed-author:KankovaMM | lld:pubmed |
| pubmed-article:1655638 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1655638 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:1655638 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1655638 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1655638 | pubmed:pagination | 466-71 | lld:pubmed |
| pubmed-article:1655638 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:meshHeading | pubmed-meshheading:1655638-... | lld:pubmed |
| pubmed-article:1655638 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1655638 | pubmed:articleTitle | Impairment of cytokine production in mice fed a vitamin D3-deficient diet. | lld:pubmed |
| pubmed-article:1655638 | pubmed:affiliation | Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy. | lld:pubmed |
| pubmed-article:1655638 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1655638 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1655638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1655638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1655638 | lld:pubmed |
