| pubmed-article:16547257 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16547257 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16547257 | lifeskim:mentions | umls-concept:C0010853 | lld:lifeskim |
| pubmed-article:16547257 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:16547257 | lifeskim:mentions | umls-concept:C0041348 | lld:lifeskim |
| pubmed-article:16547257 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:16547257 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16547257 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16547257 | pubmed:dateCreated | 2006-3-20 | lld:pubmed |
| pubmed-article:16547257 | pubmed:abstractText | The translocation of the microtubule-organizing center (MTOC), its associated signaling complex, and the secretory apparatus is the most characteristic early event that involves the tubulin cytoskeleton of T or NK cells after their interaction with APC or target cells. Our results show that Fyn kinase activity is essential for MTOC reorientation in an Ag-dependent system. Moreover, T cells from Fyn-deficient mice are unable to rearrange their tubulin cytoskeleton in response to anti-CD3-coated beads. Analysis of conjugates of T cells from transgenic OT-I mice with dendritic cells revealed that an antagonist peptide induces translocation of the MTOC, and that this process is impaired in T cells from Fyn(-/-) OT-I mice. In addition, Fyn deficiency significantly affects the MTOC relocation mediated by agonist peptide stimulation. These results reveal Fyn to be a key regulator of tubulin cytoskeleton reorganization in T cells. | lld:pubmed |
| pubmed-article:16547257 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16547257 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16547257 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16547257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16547257 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16547257 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16547257 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16547257 | pubmed:author | pubmed-author:Vicente-Manza... | lld:pubmed |
| pubmed-article:16547257 | pubmed:author | pubmed-author:Sánchez-Madri... | lld:pubmed |
| pubmed-article:16547257 | pubmed:author | pubmed-author:MontoyaMaría... | lld:pubmed |
| pubmed-article:16547257 | pubmed:author | pubmed-author:SanchoDavidD | lld:pubmed |
| pubmed-article:16547257 | pubmed:author | pubmed-author:AcutoOresteO | lld:pubmed |
| pubmed-article:16547257 | pubmed:author | pubmed-author:Gordón-Alonso... | lld:pubmed |
| pubmed-article:16547257 | pubmed:author | pubmed-author:AlarcónBalbin... | lld:pubmed |
| pubmed-article:16547257 | pubmed:author | pubmed-author:MichelFrédéri... | lld:pubmed |
| pubmed-article:16547257 | pubmed:author | pubmed-author:FernándezEdga... | lld:pubmed |
| pubmed-article:16547257 | pubmed:author | pubmed-author:Martín-Cófrec... | lld:pubmed |
| pubmed-article:16547257 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16547257 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16547257 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:16547257 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16547257 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16547257 | pubmed:pagination | 4201-7 | lld:pubmed |
| pubmed-article:16547257 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16547257 | pubmed:meshHeading | pubmed-meshheading:16547257... | lld:pubmed |
| pubmed-article:16547257 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16547257 | pubmed:articleTitle | Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR. | lld:pubmed |
| pubmed-article:16547257 | pubmed:affiliation | Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Spain. | lld:pubmed |
| pubmed-article:16547257 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16547257 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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