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pubmed-article:16547159pubmed:abstractTextPavlovian stimuli can markedly elevate instrumental responding, an effect known as Pavlovian-instrumental transfer (PIT). As the role of the ventral tegmental area (VTA) in PIT is yet unknown, we examined the effects of transient VTA inactivation by direct microinjections of a mixture of the GABA(A) and GABA(B) receptor agonists, muscimol and baclofen. Results reveal that PIT, i.e., the increase in instrumental responding during presentation of a Pavlovian stimulus, was abolished by intra-VTA microinjections of muscimol/baclofen. These data provide the first evidence that the VTA mediates Pavlovian influences on instrumental behavior.lld:pubmed
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pubmed-article:16547159pubmed:articleTitleInactivation of the ventral tegmental area abolished the general excitatory influence of Pavlovian cues on instrumental performance.lld:pubmed
pubmed-article:16547159pubmed:affiliationAbteilung Tierphysiologie, Biologisches Institut Universität Stuttgart, D-70550 Stuttgart, Germany.lld:pubmed
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