| pubmed-article:16546135 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16546135 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16546135 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:16546135 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16546135 | lifeskim:mentions | umls-concept:C0018873 | lld:lifeskim |
| pubmed-article:16546135 | lifeskim:mentions | umls-concept:C0144576 | lld:lifeskim |
| pubmed-article:16546135 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16546135 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16546135 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16546135 | lifeskim:mentions | umls-concept:C0052575 | lld:lifeskim |
| pubmed-article:16546135 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:16546135 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16546135 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16546135 | pubmed:dateCreated | 2006-3-27 | lld:pubmed |
| pubmed-article:16546135 | pubmed:abstractText | Astrin is a microtubule-associated protein and localizes with mitotic spindles in the M-phase. We silenced the expression of astrin protein and tested the cell viability in response to paclitaxel treatment in paclitaxel-sensitive and paclitaxel-resistant cells. We found that the absence of astrin by siRNA resulted in the activation of a p53-dependent apoptosis, which elevated pro-apoptotic Bax expression and increased the activity of caspase-3 in astrin-depleted cells. The HPV18 E6 transcription was found to be inhibited along with the increase expression of p53. Intriguingly, the expression of astrin decreased in paclitaxel-sensitive HeLa cells but remained steady in paclitaxel-resistant cells in response to paclitaxel treatment. Furthermore, we identified that the depletion of astrin caused more cell death both in paclitaxel-sensitive and -resistant cells in combination with paclitaxel treatment. These findings suggest that the silencing of astrin induce a p53-dependent apoptosis and has an additive effect on paclitaxel treatment. | lld:pubmed |
| pubmed-article:16546135 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16546135 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16546135 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16546135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16546135 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16546135 | pubmed:month | May | lld:pubmed |
| pubmed-article:16546135 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:16546135 | pubmed:author | pubmed-author:YangYuh-Cheng... | lld:pubmed |
| pubmed-article:16546135 | pubmed:author | pubmed-author:ChangMau-SunM... | lld:pubmed |
| pubmed-article:16546135 | pubmed:author | pubmed-author:WuChao-ChihCC | lld:pubmed |
| pubmed-article:16546135 | pubmed:author | pubmed-author:HsuYun-TingYT | lld:pubmed |
| pubmed-article:16546135 | pubmed:author | pubmed-author:ChenHsiang-Ti... | lld:pubmed |
| pubmed-article:16546135 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16546135 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:16546135 | pubmed:volume | 343 | lld:pubmed |
| pubmed-article:16546135 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16546135 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16546135 | pubmed:pagination | 428-34 | lld:pubmed |
| pubmed-article:16546135 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16546135 | pubmed:meshHeading | pubmed-meshheading:16546135... | lld:pubmed |
| pubmed-article:16546135 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16546135 | pubmed:articleTitle | Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells. | lld:pubmed |
| pubmed-article:16546135 | pubmed:affiliation | Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan. | lld:pubmed |
| pubmed-article:16546135 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16546135 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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