| pubmed-article:16542361 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16542361 | lifeskim:mentions | umls-concept:C0041296 | lld:lifeskim |
| pubmed-article:16542361 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16542361 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16542361 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16542361 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:16542361 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:16542361 | lifeskim:mentions | umls-concept:C1334114 | lld:lifeskim |
| pubmed-article:16542361 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16542361 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16542361 | pubmed:dateCreated | 2006-3-17 | lld:pubmed |
| pubmed-article:16542361 | pubmed:abstractText | Active tuberculosis (TB) is associated with prolonged suppression of Mycobacterium tuberculosis (MTB)-specific immune responses, but mechanisms involved are understood incompletely. We investigated a potential role for CD4+CD25+ regulatory T cells in depressed anti-MTB immunity by evaluating serially CD4 cell phenotype and interferon (IFN)-gamma production by mononuclear cells from patients with TB. At diagnosis, frequencies of CD4+CD25+ T cells were increased in blood from TB patients compared to healthy purified protein derivative (PPD)-positive controls (with a history of prior TB exposure), and remained elevated at completion of therapy (6 months). By contrast, expression of another activation marker, CD69, by CD4 T cells was increased at diagnosis, but declined rapidly to control levels with treatment. Among CD4+CD25+ T cells from TB patients at diagnosis those expressing high levels of CD25, probably representing regulatory T cells, were increased 2.9-fold when compared to control subjects, while MTB-stimulated IFN-gamma levels in whole blood supernatants were depressed. A role for CD4+CD25+ T cells in depressed IFN-gamma production during TB was substantiated in depletion experiments, where CD25+-depleted CD4 T cells produced increased amounts of IFN-gamma upon MTB stimulation compared to unseparated T cells. At follow-up, IFN-gamma production improved most significantly in blood from TB patients with high baseline frequencies of CD4+CD25+ T cells (more than threefold higher than controls for both total and CD25hi+ CD4 T cells), who also had a significant drop in frequencies of both total and 'regulatory' CD4+CD25+ T cells in response to treatment. Expansion of CD4+CD25+ regulatory T cells during active TB may play a role in depressed T cell IFN-gamma production. | lld:pubmed |
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| pubmed-article:16542361 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16542361 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542361 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16542361 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16542361 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16542361 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:16542361 | pubmed:author | pubmed-author:HirschC SCS | lld:pubmed |
| pubmed-article:16542361 | pubmed:author | pubmed-author:BoopW CWC | lld:pubmed |
| pubmed-article:16542361 | pubmed:author | pubmed-author:DietzeRR | lld:pubmed |
| pubmed-article:16542361 | pubmed:author | pubmed-author:RojasRR | lld:pubmed |
| pubmed-article:16542361 | pubmed:author | pubmed-author:ToossiZZ | lld:pubmed |
| pubmed-article:16542361 | pubmed:author | pubmed-author:Ribeiro-Rodri... | lld:pubmed |
| pubmed-article:16542361 | pubmed:author | pubmed-author:MacielEE | lld:pubmed |
| pubmed-article:16542361 | pubmed:author | pubmed-author:Resende CoTT | lld:pubmed |
| pubmed-article:16542361 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16542361 | pubmed:volume | 144 | lld:pubmed |
| pubmed-article:16542361 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16542361 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16542361 | pubmed:pagination | 25-34 | lld:pubmed |
| pubmed-article:16542361 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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