| pubmed-article:16541086 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16541086 | lifeskim:mentions | umls-concept:C0026605 | lld:lifeskim |
| pubmed-article:16541086 | lifeskim:mentions | umls-concept:C0041249 | lld:lifeskim |
| pubmed-article:16541086 | lifeskim:mentions | umls-concept:C0170657 | lld:lifeskim |
| pubmed-article:16541086 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:16541086 | lifeskim:mentions | umls-concept:C0679109 | lld:lifeskim |
| pubmed-article:16541086 | lifeskim:mentions | umls-concept:C0021147 | lld:lifeskim |
| pubmed-article:16541086 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:16541086 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:16541086 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:16541086 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:16541086 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:16541086 | pubmed:dateCreated | 2006-9-18 | lld:pubmed |
| pubmed-article:16541086 | pubmed:abstractText | The serotonin (5-HT) system is implicated in incentive motivational processes. The present study utilized the acute tryptophan depletion (ATD) procedure to investigate the effect of temporarily lowering 5-HT synthesis on motivation in healthy volunteers, stratifying the results by allelic variation at the serotonin transporter gene (5-HTTLPR). ATD resulted in a robust reduction in plasma tryptophan concentration. Consistent with a previous study, ATD attenuated motivationally speeded action on the Cued-Reinforcement Reaction Time task. The present investigation revealed that this effect was restricted to volunteers of the ss genotype, whereas ll volunteers exhibited intact motivationally speeded action following ATD (treatment x reinforcement probability x genotype interaction: F1,26=5.8, p=0.024). Furthermore, tryptophan availability to the brain was correlated positively with motivationally speeded action following ATD in the ss genotype group (rho13=0.71, p=0.006), whereas this correlation was negative in the ll genotype group (rho14=-0.60, p=0.023). This is the first study to suggest that allelic variation at the 5-HTTLPR mediates motivational responses to ATD in healthy volunteers. These data indicate that the s allele at the 5-HTTLPR may confer risk for depression via its effect on incentive motivational processing, and highlight the importance of genetic variation in determining individual responses to pharmacological treatments. | lld:pubmed |
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| pubmed-article:16541086 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16541086 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16541086 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16541086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16541086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16541086 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16541086 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16541086 | pubmed:issn | 0893-133X | lld:pubmed |
| pubmed-article:16541086 | pubmed:author | pubmed-author:RobbinsTrevor... | lld:pubmed |
| pubmed-article:16541086 | pubmed:author | pubmed-author:RubinszteinDa... | lld:pubmed |
| pubmed-article:16541086 | pubmed:author | pubmed-author:CoolsRoshanR | lld:pubmed |
| pubmed-article:16541086 | pubmed:author | pubmed-author:ClarkLukeL | lld:pubmed |
| pubmed-article:16541086 | pubmed:author | pubmed-author:SahakianBarba... | lld:pubmed |
| pubmed-article:16541086 | pubmed:author | pubmed-author:BlackwellAndr... | lld:pubmed |
| pubmed-article:16541086 | pubmed:author | pubmed-author:RoiserJonatha... | lld:pubmed |
| pubmed-article:16541086 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16541086 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:16541086 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16541086 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16541086 | pubmed:pagination | 2264-72 | lld:pubmed |
| pubmed-article:16541086 | pubmed:dateRevised | 2011-5-18 | lld:pubmed |
| pubmed-article:16541086 | pubmed:meshHeading | pubmed-meshheading:16541086... | lld:pubmed |
| pubmed-article:16541086 | pubmed:meshHeading | pubmed-meshheading:16541086... | lld:pubmed |
