| pubmed-article:16540568 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16540568 | lifeskim:mentions | umls-concept:C0013384 | lld:lifeskim |
| pubmed-article:16540568 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:16540568 | lifeskim:mentions | umls-concept:C1415300 | lld:lifeskim |
| pubmed-article:16540568 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16540568 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:16540568 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16540568 | pubmed:dateCreated | 2006-3-16 | lld:pubmed |
| pubmed-article:16540568 | pubmed:abstractText | Abnormal function of NMDA receptor has been suggested to be correlated with the pathogenesis of Parkinson's disease (PD) as well as with the development of l-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia. Here we show that NMDA receptor NR2 subunits display specific alterations of their subcellular distribution in striata from unilateral 6-hydroxydopamine-lesioned, L-DOPA-treated dyskinetic, and L-DOPA-treated nondyskinetic rats. Dyskinetic animals have significantly higher levels of NR2A subunit in the postsynaptic compartment than all other experimental groups, whereas NR2B subunit shows a significant reduction in both dopamine-denervated and dyskinetic rats. These events are paralleled by profound modifications of NMDA receptor NR2B subunit association with interacting elements, i.e., members of the membrane-associated guanylate kinase (MAGUK) protein family postsynaptic density-95, synapse-associated protein-97 and synapse-associated protein-102. Treatment of nondyskinetic animals with a synthetic peptide (TAT2B) able to affect NR2B binding to MAGUK proteins as well as synaptic localization of this subunit in nondyskinetic rats was sufficient to induce a shift of treated rats toward a dyskinetic motor behavior. These data indicate abnormal NR2B redistribution between synaptic and extrasynaptic membranes as an important molecular disturbance of the glutamatergic synapse involved in L-DOPA-induced dyskinesia. | lld:pubmed |
| pubmed-article:16540568 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16540568 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16540568 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16540568 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16540568 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:16540568 | pubmed:author | pubmed-author:CattabeniFlam... | lld:pubmed |
| pubmed-article:16540568 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:16540568 | pubmed:author | pubmed-author:PicconiBarbar... | lld:pubmed |
| pubmed-article:16540568 | pubmed:author | pubmed-author:BernardiGiorg... | lld:pubmed |
| pubmed-article:16540568 | pubmed:author | pubmed-author:CalabresiPaol... | lld:pubmed |
| pubmed-article:16540568 | pubmed:author | pubmed-author:GardoniFabriz... | lld:pubmed |
| pubmed-article:16540568 | pubmed:author | pubmed-author:GhiglieriVero... | lld:pubmed |
| pubmed-article:16540568 | pubmed:author | pubmed-author:PolliFederica... | lld:pubmed |
| pubmed-article:16540568 | pubmed:author | pubmed-author:BagettaVincen... | lld:pubmed |
| pubmed-article:16540568 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16540568 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16540568 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16540568 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16540568 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16540568 | pubmed:pagination | 2914-22 | lld:pubmed |
| pubmed-article:16540568 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:meshHeading | pubmed-meshheading:16540568... | lld:pubmed |
| pubmed-article:16540568 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16540568 | pubmed:articleTitle | A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. | lld:pubmed |
| pubmed-article:16540568 | pubmed:affiliation | Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy. | lld:pubmed |
| pubmed-article:16540568 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16540568 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:24409 | entrezgene:pubmed | pubmed-article:16540568 | lld:entrezgene |
| entrez-gene:24410 | entrezgene:pubmed | pubmed-article:16540568 | lld:entrezgene |
| entrez-gene:25252 | entrezgene:pubmed | pubmed-article:16540568 | lld:entrezgene |
| entrez-gene:29495 | entrezgene:pubmed | pubmed-article:16540568 | lld:entrezgene |
| entrez-gene:58948 | entrezgene:pubmed | pubmed-article:16540568 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16540568 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16540568 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16540568 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16540568 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16540568 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16540568 | lld:pubmed |
