| pubmed-article:1653911 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1653911 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:1653911 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:1653911 | lifeskim:mentions | umls-concept:C0001492 | lld:lifeskim |
| pubmed-article:1653911 | lifeskim:mentions | umls-concept:C0108066 | lld:lifeskim |
| pubmed-article:1653911 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1653911 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1653911 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1653911 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1653911 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:1653911 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1653911 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1653911 | pubmed:dateCreated | 1991-10-16 | lld:pubmed |
| pubmed-article:1653911 | pubmed:abstractText | Specific receptors for calcitonin gene-related peptide (CGRP) were identified and characterized on plasma membranes from the interleukin-1 secreting murine macrophage-like cells line P388 D1. The binding of [125I]-rat CGRP I was time-dependent, reversible and the rate of dissociation of [125I]-rat CGRP I increased in the presence of GTP. Scatchard analysis was consistent with a single class of binding sites, with an apparent dissociation constant of 1.76 nM and a maximal binding capacity of 85.48 fmol/mg protein. In competitive displacement studies, rat CGRP I, human CGRP I and human CGRP II were equipotent to inhibit the binding of [125I]-rat CGRP I (IC50 = 4 nM) while rat CGRP II and the synthetic analogue [tyr(o)]-human CGRP I were ten-fold less potent. Porcine calcitonin and VIP did not inhibit tracer binding. In the presence of GTP, CGRP stimulation of adenylate cyclase was dose-dependent and strongly correlated with receptor occupation. These results indicate that the P388 D1 macrophage-like cell line expresses CGRP specific receptors functionally coupled to adenylate cyclase, which may be involved in CGRP-mediated macrophage immune response. | lld:pubmed |
| pubmed-article:1653911 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1653911 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1653911 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1653911 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1653911 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1653911 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1653911 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1653911 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1653911 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1653911 | pubmed:month | May | lld:pubmed |
| pubmed-article:1653911 | pubmed:issn | 0143-4179 | lld:pubmed |
| pubmed-article:1653911 | pubmed:author | pubmed-author:RevillardJ... | lld:pubmed |
| pubmed-article:1653911 | pubmed:author | pubmed-author:ChayvialleJ... | lld:pubmed |
| pubmed-article:1653911 | pubmed:author | pubmed-author:CuberJ CJC | lld:pubmed |
| pubmed-article:1653911 | pubmed:author | pubmed-author:KaiserlianDD | lld:pubmed |
| pubmed-article:1653911 | pubmed:author | pubmed-author:AbelloJJ | lld:pubmed |
| pubmed-article:1653911 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1653911 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:1653911 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1653911 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1653911 | pubmed:pagination | 43-9 | lld:pubmed |
| pubmed-article:1653911 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1653911 | pubmed:meshHeading | pubmed-meshheading:1653911-... | lld:pubmed |
| pubmed-article:1653911 | pubmed:meshHeading | pubmed-meshheading:1653911-... | lld:pubmed |
| pubmed-article:1653911 | pubmed:meshHeading | pubmed-meshheading:1653911-... | lld:pubmed |
| pubmed-article:1653911 | pubmed:meshHeading | pubmed-meshheading:1653911-... | lld:pubmed |
| pubmed-article:1653911 | pubmed:meshHeading | pubmed-meshheading:1653911-... | lld:pubmed |
| pubmed-article:1653911 | pubmed:meshHeading | pubmed-meshheading:1653911-... | lld:pubmed |
| pubmed-article:1653911 | pubmed:meshHeading | pubmed-meshheading:1653911-... | lld:pubmed |
| pubmed-article:1653911 | pubmed:meshHeading | pubmed-meshheading:1653911-... | lld:pubmed |
| pubmed-article:1653911 | pubmed:meshHeading | pubmed-meshheading:1653911-... | lld:pubmed |
| pubmed-article:1653911 | pubmed:meshHeading | pubmed-meshheading:1653911-... | lld:pubmed |
| pubmed-article:1653911 | pubmed:meshHeading | pubmed-meshheading:1653911-... | lld:pubmed |
| pubmed-article:1653911 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1653911 | pubmed:articleTitle | Characterization of calcitonin gene-related peptide receptors and adenylate cyclase response in the murine macrophage cell line P388 D1. | lld:pubmed |
| pubmed-article:1653911 | pubmed:affiliation | Inserm U 45, Hôpital Edouard Herriot, Lyon, France. | lld:pubmed |
| pubmed-article:1653911 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1653911 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1653911 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1653911 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1653911 | lld:pubmed |
