| pubmed-article:16539040 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16539040 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16539040 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:16539040 | lifeskim:mentions | umls-concept:C0598034 | lld:lifeskim |
| pubmed-article:16539040 | lifeskim:mentions | umls-concept:C0023273 | lld:lifeskim |
| pubmed-article:16539040 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:16539040 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:16539040 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16539040 | pubmed:dateCreated | 2006-3-16 | lld:pubmed |
| pubmed-article:16539040 | pubmed:abstractText | The breast cancer susceptibility protein BRCA2 is implicated in the DNA double-strand break (DSB) repair pathway through its association with Rad51. It is almost a ubiquitous eukaryotic protein; homologs of the BRCA2 gene (BRH2) have been identified in many mammals, as well as nonmammals. As a part of our quest to understand the DNA damage, repair, and recombination process in the parasitic protozoan, Leishmania sp., we have cloned and characterized a BRCA2 homolog from Leishmania sp. (LBRH2). LBRH2 is coded by a single-copy gene (ORF = 3,498 bp) located at the 700-kb chromosome 16. The transcripts in both the promastigotes and the amastigotes are approximately 3.9 kilonucleotides (knt) in size, corresponding to a protein with a calculated molecular mass of 128 kDa. The primary transcript of the gene is alternatively trans-spliced to produce 3 distinct mRNAs with altered folded structures at their 5' ends. This study will contribute toward the understanding of a potential RAD51-mediated DNA recombination/repair pathway in Leishmania sp. | lld:pubmed |
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| pubmed-article:16539040 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16539040 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16539040 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16539040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16539040 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16539040 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16539040 | pubmed:issn | 0022-3395 | lld:pubmed |
| pubmed-article:16539040 | pubmed:author | pubmed-author:ChaudhuriGaut... | lld:pubmed |
| pubmed-article:16539040 | pubmed:author | pubmed-author:MisraSmitaS | lld:pubmed |
| pubmed-article:16539040 | pubmed:author | pubmed-author:HallMackM3rd | lld:pubmed |
| pubmed-article:16539040 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16539040 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:16539040 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16539040 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16539040 | pubmed:pagination | 1492-5 | lld:pubmed |
| pubmed-article:16539040 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:16539040 | pubmed:meshHeading | pubmed-meshheading:16539040... | lld:pubmed |
| pubmed-article:16539040 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16539040 | pubmed:articleTitle | Molecular characterization of a human BRCA2 homolog in Leishmania donovani. | lld:pubmed |
| pubmed-article:16539040 | pubmed:affiliation | Division of Microbial Pathogenesis & Immune Response, Department of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee 37208, USA. | lld:pubmed |
| pubmed-article:16539040 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16539040 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16539040 | lld:pubmed |
