| pubmed-article:16537510 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16537510 | lifeskim:mentions | umls-concept:C1335877 | lld:lifeskim |
| pubmed-article:16537510 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16537510 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:16537510 | lifeskim:mentions | umls-concept:C0178555 | lld:lifeskim |
| pubmed-article:16537510 | lifeskim:mentions | umls-concept:C0279023 | lld:lifeskim |
| pubmed-article:16537510 | lifeskim:mentions | umls-concept:C2827395 | lld:lifeskim |
| pubmed-article:16537510 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16537510 | pubmed:dateCreated | 2006-3-15 | lld:pubmed |
| pubmed-article:16537510 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16537510 | pubmed:abstractText | The molecular mechanisms by which transcription is selectively activated and precisely controlled by signal transducer and activator of transcription (Stat) factors represent a central issue in cytokine-mediated cellular responses. Stat6 mediates responses to IL-4 and antagonizes Stat1 activated by IFN-gamma. We have discovered that Stat6 binds to collaborator of Stat6 (CoaSt6), a protein that lacks conventional coactivator motifs but contains three iterations of a domain found in the variant histone macroH2A. Although macroH2A participates in transcriptional silencing, the macro domains of CoaSt6 increased IL-4-induced gene expression. Moreover, CoaSt6 amplified Stat6-mediated but not IFN-gamma-induced gene expression, providing evidence of a selective coregulator of Stat-mediated gene transcription. | lld:pubmed |
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| pubmed-article:16537510 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16537510 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16537510 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16537510 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16537510 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16537510 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:16537510 | pubmed:author | pubmed-author:BoothbyMarkM | lld:pubmed |
| pubmed-article:16537510 | pubmed:author | pubmed-author:GoenkaShreevr... | lld:pubmed |
| pubmed-article:16537510 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16537510 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:16537510 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:16537510 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16537510 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16537510 | pubmed:pagination | 4210-5 | lld:pubmed |
| pubmed-article:16537510 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16537510 | pubmed:meshHeading | pubmed-meshheading:16537510... | lld:pubmed |
| pubmed-article:16537510 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16537510 | pubmed:articleTitle | Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor. | lld:pubmed |
