| pubmed-article:16522774 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16522774 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:16522774 | lifeskim:mentions | umls-concept:C0026922 | lld:lifeskim |
| pubmed-article:16522774 | lifeskim:mentions | umls-concept:C0023343 | lld:lifeskim |
| pubmed-article:16522774 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:16522774 | lifeskim:mentions | umls-concept:C0011900 | lld:lifeskim |
| pubmed-article:16522774 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16522774 | pubmed:dateCreated | 2006-3-8 | lld:pubmed |
| pubmed-article:16522774 | pubmed:abstractText | Despite the success of multidrug therapy in reducing the number of registered leprosy cases worldwide, evidence suggests that Mycobacterium leprae continues to be transmitted. A serological diagnostic test capable of identifying and allowing treatment of early-stage disease could reduce transmission and prevent the onset of the disability, a common complication of the disease in later stages. Serological diagnosis based on antibody recognition of phenolic glycolipid I (PGL-I) cannot reliably identify individuals with lower bacterial indices (BI). One strategy that might improve this situation is the provision of highly specific serological antigens that may be combined with PGL-I to improve the sensitivity of diagnosis. Using serological expression cloning with a serum pool of untreated lepromatous leprosy (LL) patients, we identified 14 strongly reactive M. leprae proteins, 5 of which were previously unstudied. We present results suggesting that two of these proteins, ML0405 and ML2331, demonstrate the ability to specifically identify LL/borderline lepromatous (BL) patients on the basis of immunoglobulin G (IgG) reactivity. In a household contact study, LL index cases were identified on the basis of this reactivity, while household contacts of these patients demonstrated undetectable reactivity. At a serum dilution of 1:800, suitable to reduce background PGL-I IgM reactivity, two BL patients with a BI of <4 showed anti-human polyvalent immunoglobulin G, A, and M reactivity measured with a combination of ML0405, ML2331, and natural disaccharide O-linked human serum albumin (NDOHSA) (synthetic PGL-I) that was markedly higher than IgM reactivity to NDOHSA alone. We suggest that ML0405 and ML2331 may have utility in serological leprosy diagnosis. | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16522774 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16522774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16522774 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16522774 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16522774 | pubmed:issn | 1556-6811 | lld:pubmed |
| pubmed-article:16522774 | pubmed:author | pubmed-author:SpencerJohnJ | lld:pubmed |
| pubmed-article:16522774 | pubmed:author | pubmed-author:ReedSteven... | lld:pubmed |
| pubmed-article:16522774 | pubmed:author | pubmed-author:BrennanPatric... | lld:pubmed |
| pubmed-article:16522774 | pubmed:author | pubmed-author:MohamathRaodo... | lld:pubmed |
| pubmed-article:16522774 | pubmed:author | pubmed-author:GelberRobertR | lld:pubmed |
| pubmed-article:16522774 | pubmed:author | pubmed-author:ReeceStephen... | lld:pubmed |
| pubmed-article:16522774 | pubmed:author | pubmed-author:IretonGregG | lld:pubmed |
| pubmed-article:16522774 | pubmed:author | pubmed-author:GuderianJeffr... | lld:pubmed |
| pubmed-article:16522774 | pubmed:author | pubmed-author:GotoWakakoW | lld:pubmed |
| pubmed-article:16522774 | pubmed:author | pubmed-author:GroathouseNat... | lld:pubmed |
| pubmed-article:16522774 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16522774 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:16522774 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16522774 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16522774 | pubmed:pagination | 333-40 | lld:pubmed |
| pubmed-article:16522774 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16522774 | pubmed:meshHeading | pubmed-meshheading:16522774... | lld:pubmed |
| pubmed-article:16522774 | pubmed:meshHeading | pubmed-meshheading:16522774... | lld:pubmed |
| pubmed-article:16522774 | pubmed:meshHeading | pubmed-meshheading:16522774... | lld:pubmed |
| pubmed-article:16522774 | pubmed:meshHeading | pubmed-meshheading:16522774... | lld:pubmed |
| pubmed-article:16522774 | pubmed:meshHeading | pubmed-meshheading:16522774... | lld:pubmed |
| pubmed-article:16522774 | pubmed:meshHeading | pubmed-meshheading:16522774... | lld:pubmed |
| pubmed-article:16522774 | pubmed:meshHeading | pubmed-meshheading:16522774... | lld:pubmed |
| pubmed-article:16522774 | pubmed:meshHeading | pubmed-meshheading:16522774... | lld:pubmed |
| pubmed-article:16522774 | pubmed:meshHeading | pubmed-meshheading:16522774... | lld:pubmed |
| pubmed-article:16522774 | pubmed:meshHeading | pubmed-meshheading:16522774... | lld:pubmed |
| pubmed-article:16522774 | pubmed:meshHeading | pubmed-meshheading:16522774... | lld:pubmed |
| pubmed-article:16522774 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16522774 | pubmed:articleTitle | ML0405 and ML2331 are antigens of Mycobacterium leprae with potential for diagnosis of leprosy. | lld:pubmed |
| pubmed-article:16522774 | pubmed:affiliation | IDRI, 1124 Columbia Street, Suite 400, Seattle, WA 98104, USA. sreed@idri.org | lld:pubmed |
| pubmed-article:16522774 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16522774 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16522774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16522774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16522774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16522774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16522774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16522774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16522774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16522774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16522774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16522774 | lld:pubmed |
