| pubmed-article:1651914 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1651914 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:1651914 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:1651914 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:1651914 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:1651914 | pubmed:dateCreated | 1991-9-26 | lld:pubmed |
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| pubmed-article:1651914 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651914 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651914 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651914 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651914 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1651914 | pubmed:abstractText | There are two isozymes of angiotensin-converting enzyme (ACE), one produced by somatic tissues and a smaller protein synthesized by developing spermatozoa (testis ACE). To investigate the molecular control of testis ACE, we generated mice transgenic for a construct containing a putative testis-specific ACE promoter linked to the Escherichia coli reporter gene encoding beta-galactosidase. The transgenic mice express beta-galactosidase protein and RNA only within the testis. Histochemical analysis of the transgenic mice shows co-localization of beta-galactosidase protein and endogenous ACE within elongating spermatozoa. These studies demonstrate that transcription of testis ACE is controlled by a strong intragenic testis-specific promoter that is contained within a 698-base pair fragment immediately upstream from the transcription start site of testis ACE. Characterization of the testis ACE promoter may provide insights into the molecular mechanisms controlling cell stage-specific gene expression in the male germ line. | lld:pubmed |
| pubmed-article:1651914 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651914 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1651914 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651914 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1651914 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1651914 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651914 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1651914 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1651914 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:1651914 | pubmed:author | pubmed-author:BernsteinK... | lld:pubmed |
| pubmed-article:1651914 | pubmed:author | pubmed-author:OverbeekP APA | lld:pubmed |
| pubmed-article:1651914 | pubmed:author | pubmed-author:ShaiS YSY | lld:pubmed |
| pubmed-article:1651914 | pubmed:author | pubmed-author:HowardT ETE | lld:pubmed |
| pubmed-article:1651914 | pubmed:author | pubmed-author:LangfordK GKG | lld:pubmed |
| pubmed-article:1651914 | pubmed:author | pubmed-author:KovacM JMJ | lld:pubmed |
| pubmed-article:1651914 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1651914 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:1651914 | pubmed:volume | 266 | lld:pubmed |
| pubmed-article:1651914 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1651914 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1651914 | pubmed:pagination | 15559-62 | lld:pubmed |
| pubmed-article:1651914 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:1651914 | pubmed:meshHeading | pubmed-meshheading:1651914-... | lld:pubmed |
| pubmed-article:1651914 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1651914 | pubmed:articleTitle | Transgenic mice demonstrate a testis-specific promoter for angiotensin-converting enzyme. | lld:pubmed |
| pubmed-article:1651914 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322. | lld:pubmed |
| pubmed-article:1651914 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1651914 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1651914 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:11421 | entrezgene:pubmed | pubmed-article:1651914 | lld:entrezgene |
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