| pubmed-article:16517696 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16517696 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:16517696 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:16517696 | lifeskim:mentions | umls-concept:C0205991 | lld:lifeskim |
| pubmed-article:16517696 | lifeskim:mentions | umls-concept:C1306235 | lld:lifeskim |
| pubmed-article:16517696 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:16517696 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:16517696 | lifeskim:mentions | umls-concept:C0152060 | lld:lifeskim |
| pubmed-article:16517696 | lifeskim:mentions | umls-concept:C1527180 | lld:lifeskim |
| pubmed-article:16517696 | lifeskim:mentions | umls-concept:C0205154 | lld:lifeskim |
| pubmed-article:16517696 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16517696 | pubmed:dateCreated | 2006-3-6 | lld:pubmed |
| pubmed-article:16517696 | pubmed:abstractText | Ligation of CD28 during Ag recognition plays an important role in the generation of effective T cell responses. However, its peripheral control of regulatory T cell function remains obscure. In this study, we show that naive wild-type or CD28(-/-) CD4(+)CD25(-) T cells exposed to peptide in vivo develop regulatory activity that suppresses the response of adoptively transferred naive T cells to a subsequent immunogenic challenge. We find that although CD28 is engaged during the initial peptide-priming event and is essential to sustain T cell survival, it is not sufficient to prevent the dominance of regulatory T cell function. Immunization with adjuvant abrogates regulatory dominance, reducing overall Foxp3 expression in a CD28-dependent manner. We conclude that CD28 licenses active immunization by regulating Ag-induced immunoregulation. | lld:pubmed |
| pubmed-article:16517696 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517696 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517696 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16517696 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517696 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16517696 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517696 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517696 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517696 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517696 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16517696 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16517696 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16517696 | pubmed:author | pubmed-author:SadelainMiche... | lld:pubmed |
| pubmed-article:16517696 | pubmed:author | pubmed-author:GajewskaBeata... | lld:pubmed |
| pubmed-article:16517696 | pubmed:author | pubmed-author:FurtadoGlauci... | lld:pubmed |
| pubmed-article:16517696 | pubmed:author | pubmed-author:SantosElmerE | lld:pubmed |
| pubmed-article:16517696 | pubmed:author | pubmed-author:LyddaneClayC | lld:pubmed |
| pubmed-article:16517696 | pubmed:author | pubmed-author:KingPhilip... | lld:pubmed |
| pubmed-article:16517696 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16517696 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16517696 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:16517696 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16517696 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16517696 | pubmed:pagination | 3306-10 | lld:pubmed |
| pubmed-article:16517696 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16517696 | pubmed:meshHeading | pubmed-meshheading:16517696... | lld:pubmed |
| pubmed-article:16517696 | pubmed:meshHeading | pubmed-meshheading:16517696... | lld:pubmed |
| pubmed-article:16517696 | pubmed:meshHeading | pubmed-meshheading:16517696... | lld:pubmed |
| pubmed-article:16517696 | pubmed:meshHeading | pubmed-meshheading:16517696... | lld:pubmed |
| pubmed-article:16517696 | pubmed:meshHeading | pubmed-meshheading:16517696... | lld:pubmed |
| pubmed-article:16517696 | pubmed:meshHeading | pubmed-meshheading:16517696... | lld:pubmed |
| pubmed-article:16517696 | pubmed:meshHeading | pubmed-meshheading:16517696... | lld:pubmed |
| pubmed-article:16517696 | pubmed:meshHeading | pubmed-meshheading:16517696... | lld:pubmed |
| pubmed-article:16517696 | pubmed:meshHeading | pubmed-meshheading:16517696... | lld:pubmed |
| pubmed-article:16517696 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16517696 | pubmed:articleTitle | Cutting Edge: CD28 controls dominant regulatory T cell activity during active immunization. | lld:pubmed |
| pubmed-article:16517696 | pubmed:affiliation | Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. | lld:pubmed |
| pubmed-article:16517696 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16517696 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16517696 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:12487 | entrezgene:pubmed | pubmed-article:16517696 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16517696 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517696 | lld:pubmed |
