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pubmed-article:16517222pubmed:abstractTextAn analytical procedure was developed and validated for the quantification of clotiazepam in human plasma. After subjecting plasma samples to solid-phase extraction, the extract was evaporated and the residue re-constituted. An aliquot of the mixture was injected onto a gas chromatography-mass spectrometry system. The detector response was linear for clotiazepam concentrations in the range of 5-200 ng/ml. Intra- and inter-day precision for the assay over the concentration range was below 13.1 and 13.5%, and the accuracy ranged between 99.0-107.9% and 92.4-101.3%, respectively. The drug was found to be stable under various processing conditions used. The method is applicable to human pharmacokinetic studies of clotiazepam.lld:pubmed
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pubmed-article:16517222pubmed:authorpubmed-author:ChungSuk-JaeS...lld:pubmed
pubmed-article:16517222pubmed:authorpubmed-author:ShimChang-Koo...lld:pubmed
pubmed-article:16517222pubmed:authorpubmed-author:KimDae-DukDDlld:pubmed
pubmed-article:16517222pubmed:authorpubmed-author:AhnSung-HoonS...lld:pubmed
pubmed-article:16517222pubmed:authorpubmed-author:MaengHan-JooH...lld:pubmed
pubmed-article:16517222pubmed:authorpubmed-author:KooTae-SungTSlld:pubmed
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pubmed-article:16517222pubmed:pagination128-33lld:pubmed
pubmed-article:16517222pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16517222pubmed:year2006lld:pubmed
pubmed-article:16517222pubmed:articleTitleQuantification of clotiazepam in human plasma by gas chromatography-mass spectrometry.lld:pubmed
pubmed-article:16517222pubmed:affiliationDepartment of Pharmaceutics, College of Pharmacy, Seoul National University, San 56-1, Shinlim-dong, Kwanak-gu, 151-742, South Korea.lld:pubmed
pubmed-article:16517222pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16517222pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:16517222pubmed:publicationTypeValidation Studieslld:pubmed