| pubmed-article:16513351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16513351 | lifeskim:mentions | umls-concept:C0031607 | lld:lifeskim |
| pubmed-article:16513351 | lifeskim:mentions | umls-concept:C0023693 | lld:lifeskim |
| pubmed-article:16513351 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16513351 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16513351 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:16513351 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16513351 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16513351 | lifeskim:mentions | umls-concept:C0806909 | lld:lifeskim |
| pubmed-article:16513351 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16513351 | pubmed:dateCreated | 2006-4-3 | lld:pubmed |
| pubmed-article:16513351 | pubmed:abstractText | The Drosophila phototransduction cascade serves as a paradigm for characterizing the regulation of sensory signaling and TRP channels in vivo . Activation of these channels requires phospholipase C (PLC) and may depend on subsequent production of diacylglycerol (DAG) and downstream metabolites . DAG could potentially be produced through a second pathway involving the combined activities of a phospholipase D (PLD) and a phosphatidic acid (PA) phosphatase (PAP). However, a role for a PAP in the regulation of TRP channels has not been described. Here, we report the identification of a PAP, referred to as Lazaro (Laza). Mutations in laza caused a reduction in the light response and faster termination kinetics. Loss of laza suppressed the severity of the phenotype caused by mutation of the DAG kinase, RDGA , indicating that Laza functions in opposition to RDGA. We also showed that the retinal degeneration resulting from overexpression of the PLD was suppressed by elimination of Laza. These data demonstrate a requirement for a PLD/PAP-dependent pathway for achieving the maximal light response. The genetic interactions with both rdgA and Pld indicate that Laza functions in the convergence of both PLC- and PLD-coupled signaling in vivo. | lld:pubmed |
| pubmed-article:16513351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16513351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16513351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16513351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16513351 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16513351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16513351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16513351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16513351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16513351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16513351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16513351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16513351 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16513351 | pubmed:issn | 0960-9822 | lld:pubmed |
| pubmed-article:16513351 | pubmed:author | pubmed-author:MontellCraigC | lld:pubmed |
| pubmed-article:16513351 | pubmed:author | pubmed-author:KwonYoungY | lld:pubmed |
| pubmed-article:16513351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16513351 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:16513351 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:16513351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16513351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16513351 | pubmed:pagination | 723-9 | lld:pubmed |
| pubmed-article:16513351 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16513351 | pubmed:meshHeading | pubmed-meshheading:16513351... | lld:pubmed |
| pubmed-article:16513351 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16513351 | pubmed:articleTitle | Dependence on the Lazaro phosphatidic acid phosphatase for the maximum light response. | lld:pubmed |
| pubmed-article:16513351 | pubmed:affiliation | Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. | lld:pubmed |
| pubmed-article:16513351 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16513351 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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