Linked Life Data

16507843

Source:http://linkedlifedata.com/resource/pubmed/id/16507843

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pubmed-article:16507843pubmed:dateCreated2006-3-1lld:pubmed
pubmed-article:16507843pubmed:abstractTextTo investigate why human leukocyte-associated antigen-DRB1*0301 (HLA-DRB1*0301) positive Scandinavian patients have a better prognosis than HLA-DRB1*0301 negative patients, the present authors examined patterns of cytokine expression in bronchoalveolar lavage (BAL) cells and BAL fluid (BALF) from patients with pulmonary sarcoidosis and controls. Using real-time PCR, the mRNA expression of selected cytokines in BAL cells from newly diagnosed, untreated nonsmoking patients (n=25) and controls (n=11) was quantified. Cytokine protein levels in BALF from patients (n=34) and controls (n=11) were assessed using cytometric bead array. The patients were evaluated and stratified into two subgroups: HLA-DRB1*0301 positive (all with an acute onset) and HLA-DRB1*0301 negative (all with an insidious onset). When comparing patients and controls, BAL cells of the patients expressed significantly higher levels of interferon (IFN)-gamma and interleukin (IL)-10 mRNA. There were significantly decreased IFN-gamma and tumour necrosis factor (TNF)-alpha mRNA levels, and a tendency toward higher levels of transforming growth factor-beta1 mRNA in HLA-DRB1*0301 positive compared with HLA-DRB1*0301 negative patients. Protein levels of IL-1beta, IL-2, IL-6, IL-12p70 and TNF-alpha in BALF were significantly higher in patients. HLA-DRB1*0301 positive patients exhibited tendencies to lower levels of most cytokines in BALF. In conclusion, the present data show a reduced expression of T-helper cell type-1 cytokines in human leukocyte-associated antigen-DRB1*0301 positive patients, which may relate to their good prognosis.lld:pubmed
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pubmed-article:16507843pubmed:pagination451-9lld:pubmed
pubmed-article:16507843pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:16507843pubmed:year2006lld:pubmed
pubmed-article:16507843pubmed:articleTitleReduced Th1 response in the lungs of HLA-DRB1*0301 patients with pulmonary sarcoidosis.lld:pubmed
pubmed-article:16507843pubmed:affiliationDept of Medicine, Division of Respiratory Medicine, Immune and Gene Therapy Laboratory, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden. Farah.Idali@medks.ki.selld:pubmed
pubmed-article:16507843pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16507843pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:16507843pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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