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pubmed-article:16505647pubmed:abstractTextSystemic inflammatory response (SIRS) and severe SIRS (SIRS with organ dysfunction) occurring after cardiopulmonary bypass (CPB) are common causes of morbidity and mortality among cardiac surgical patients. These syndromes are often preceded by a profound vasodilation, characterized by vasoplegia occurring during surgery. Many substances have been implicated in their pathophysiology. Adenosine is a strong endogenous vasodilating agent released by endothelial cells and myocytes under metabolic stress and may be involved in blood pressure failure during CPB induced by severe SIRS.lld:pubmed
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pubmed-article:16505647pubmed:articleTitleRole of endogenous adenosine as a predictive marker of vasoplegia during cardiopulmonary bypass and postoperative severe systemic inflammatory response.lld:pubmed
pubmed-article:16505647pubmed:affiliationDépartement d'Anesthésie-Réanimation Adulte, Groupe Hospitalier de La Timone, and FRE 2738 CNRS Université de la Méditerranée, Marseille, France.lld:pubmed
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