| pubmed-article:16505462 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16505462 | lifeskim:mentions | umls-concept:C0019196 | lld:lifeskim |
| pubmed-article:16505462 | lifeskim:mentions | umls-concept:C0033131 | lld:lifeskim |
| pubmed-article:16505462 | lifeskim:mentions | umls-concept:C1552617 | lld:lifeskim |
| pubmed-article:16505462 | lifeskim:mentions | umls-concept:C0282443 | lld:lifeskim |
| pubmed-article:16505462 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16505462 | pubmed:dateCreated | 2006-2-28 | lld:pubmed |
| pubmed-article:16505462 | pubmed:abstractText | Primary care physicians see many of the estimated 250 000 Canadians chronically infected with the hepatitis C virus (HCV). Of this number, about one-third are unaware they are infected, which constitutes a large hidden epidemic. They continue to spread HCV unknowingly and cannot benefit from advances in antiviral therapy that may clear them of the virus. Many HCV-infected people remain asymptomatic, which means it is important to assess for risk factors and test patients accordingly. The third-generation enzyme immunoassay for HCV antibodies is a sensitive and specific test, although the presence of the virus can be confirmed by polymerase chain reaction testing for HCV RNA in some circumstances. Pegylated interferon-alpha and ribavirin combination therapy clears the virus in about 45%-80% of patients, depending on viral genotype. Preventive strategies and counselling recommendations are also reviewed. | lld:pubmed |
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