| pubmed-article:16505142 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16505142 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16505142 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:16505142 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:16505142 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:16505142 | lifeskim:mentions | umls-concept:C1150095 | lld:lifeskim |
| pubmed-article:16505142 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:16505142 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:16505142 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:16505142 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16505142 | pubmed:dateCreated | 2006-3-21 | lld:pubmed |
| pubmed-article:16505142 | pubmed:abstractText | Endoplasmic reticulum (ER)-associated aminopeptidase (ERAP)1 has been implicated in the final proteolytic processing of peptides presented by major histocompatibility complex (MHC) class I molecules. To evaluate the in vivo role of ERAP1, we have generated ERAP1-deficient mice. Cell surface expression of the class Ia molecules H-2Kb and H-2Db and of the class Ib molecule Qa-2 was significantly reduced in these animals. Although cells from mutant animals exhibited reduced capacity to present several self- and foreign antigens to Kb-, Db-, or Qa-1b-restricted CD8+ cytotoxic T cells, presentation of some antigens was unaffected or significantly enhanced. Consistent with these findings, mice generated defective CD8+ T cell responses against class I-presented antigens. These findings reveal an important in vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. | lld:pubmed |
| pubmed-article:16505142 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16505142 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16505142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505142 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16505142 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16505142 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:16505142 | pubmed:author | pubmed-author:Van KaerLucL | lld:pubmed |
| pubmed-article:16505142 | pubmed:author | pubmed-author:JoyceSebastia... | lld:pubmed |
| pubmed-article:16505142 | pubmed:author | pubmed-author:HillTimothyT | lld:pubmed |
| pubmed-article:16505142 | pubmed:author | pubmed-author:RoopenianDerr... | lld:pubmed |
| pubmed-article:16505142 | pubmed:author | pubmed-author:ParekhVrajesh... | lld:pubmed |
| pubmed-article:16505142 | pubmed:author | pubmed-author:Olivares-Vill... | lld:pubmed |
| pubmed-article:16505142 | pubmed:author | pubmed-author:Mendez-Fernan... | lld:pubmed |
| pubmed-article:16505142 | pubmed:author | pubmed-author:YanJingboJ | lld:pubmed |
| pubmed-article:16505142 | pubmed:author | pubmed-author:DragovicSrdja... | lld:pubmed |
| pubmed-article:16505142 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16505142 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:16505142 | pubmed:volume | 203 | lld:pubmed |
| pubmed-article:16505142 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16505142 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16505142 | pubmed:pagination | 647-59 | lld:pubmed |
| pubmed-article:16505142 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
