| pubmed-article:16505141 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16505141 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:16505141 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:16505141 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16505141 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16505141 | lifeskim:mentions | umls-concept:C0328767 | lld:lifeskim |
| pubmed-article:16505141 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16505141 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:16505141 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:16505141 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:16505141 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:16505141 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:16505141 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16505141 | pubmed:dateCreated | 2006-3-21 | lld:pubmed |
| pubmed-article:16505141 | pubmed:abstractText | Current human immunodeficiency virus (HIV) vaccine approaches emphasize prime boost strategies comprising multiple doses of DNA vaccine and recombinant viral vectors. We are developing a protein-based approach that directly harnesses principles for generating T cell immunity. Vaccine is delivered to maturing dendritic cells in lymphoid tissue by engineering protein antigen into an antibody to DEC-205, a receptor for antigen presentation. Here we characterize the CD4+ T cell immune response to HIV gag and compare efficacy with other vaccine strategies in a single dose. DEC-205-targeted HIV gag p24 or p41 induces stronger CD4+ T cell immunity relative to high doses of gag protein, HIV gag plasmid DNA, or recombinant adenovirus-gag. High frequencies of interferon (IFN)-gamma- and interleukin 2-producing CD4+ T cells are elicited, including double cytokine-producing cells. In addition, the response is broad because the primed mice respond to an array of peptides in different major histocompatibility complex haplotypes. Long-lived T cell memory is observed. After subcutaneous vaccination, CD4+ and IFN-gamma-dependent protection develops to a challenge with recombinant vaccinia-gag virus at a mucosal surface, the airway. We suggest that a DEC-targeted vaccine, in part because of an unusually strong and protective CD4+ T cell response, will improve vaccine efficacy as a stand-alone approach or with other modalities. | lld:pubmed |
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| pubmed-article:16505141 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16505141 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16505141 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16505141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16505141 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16505141 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16505141 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:SteinmanRalph... | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:NussenzweigMi... | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:HuangYaoxingY | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:MoranThomas... | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:MoltedoBrunoB | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:LópezCarolina... | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:ParkChae... | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:TrumpfhellerC... | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:Granelli-Pipe... | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:SoaresHelenaH | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:FinkeJennifer... | lld:pubmed |
| pubmed-article:16505141 | pubmed:author | pubmed-author:SchlesingerSa... | lld:pubmed |
| pubmed-article:16505141 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16505141 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:16505141 | pubmed:volume | 203 | lld:pubmed |
| pubmed-article:16505141 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16505141 | pubmed:authorsComplete | Y | lld:pubmed |
