| pubmed-article:1650160 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1650160 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1650160 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:1650160 | lifeskim:mentions | umls-concept:C0014556 | lld:lifeskim |
| pubmed-article:1650160 | lifeskim:mentions | umls-concept:C1510865 | lld:lifeskim |
| pubmed-article:1650160 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1650160 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:1650160 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1650160 | pubmed:dateCreated | 1991-8-29 | lld:pubmed |
| pubmed-article:1650160 | pubmed:abstractText | We examined binding to excitatory amino acid and inhibitory amino acid receptors in frozen hippocampal sections prepared from surgical specimens resected from 8 individuals with medically refractory temporal lobe epilepsy. The excitatory receptors studied included N-methyl-D-aspartate (NMDA), strychnine-insensitive glycine, phencyclidine, and quisqualate. The inhibitory receptors studied were gamma-aminobutyric acid type A (GABAA) and benzodiazepine. Excitatory and inhibitory amino acid receptor binding were differentially altered in the patients with temporal lobe epilepsy in comparison to 8 age-comparable autopsy control subjects, and changes in receptor binding were regionally selective in four areas. Binding to phencyclidine receptors associated with the NMDA channel was reduced by 35 to 70% in all regions in the hippocampi of the patients. In contrast, binding to the NMDA recognition site and its associated glycine modulatory site was elevated by 20 to 110% in the cornu ammonis (CA) 1 area and dentate gyrus of the hippocampus of the patients. Binding to these sites was unaffected in area CA4. Binding to the quisqualate-type excitatory amino acid receptor was unchanged in all regions except the stratum lacunosum moleculare CA1, where it was increased by 63%. GABAA and benzodiazepine receptor binding was reduced by 20 to 60% in CA1 and CA4, but unchanged in dentate gyrus. The data indicate that excitatory and inhibitory amino acid receptors are altered in the hippocampus of patients with temporal lobe epilepsy. | lld:pubmed |
| pubmed-article:1650160 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1650160 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1650160 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1650160 | pubmed:month | May | lld:pubmed |
| pubmed-article:1650160 | pubmed:issn | 0364-5134 | lld:pubmed |
| pubmed-article:1650160 | pubmed:author | pubmed-author:JohnstonM VMV | lld:pubmed |
| pubmed-article:1650160 | pubmed:author | pubmed-author:McKeeverP EPE | lld:pubmed |
| pubmed-article:1650160 | pubmed:author | pubmed-author:McDonaldJ WJW | lld:pubmed |
| pubmed-article:1650160 | pubmed:author | pubmed-author:SackellaresJ... | lld:pubmed |
| pubmed-article:1650160 | pubmed:author | pubmed-author:GilmanSS | lld:pubmed |
| pubmed-article:1650160 | pubmed:author | pubmed-author:HongHH | lld:pubmed |
| pubmed-article:1650160 | pubmed:author | pubmed-author:TroncosoJ CJC | lld:pubmed |
| pubmed-article:1650160 | pubmed:author | pubmed-author:GarofaloE AEA | lld:pubmed |
| pubmed-article:1650160 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1650160 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:1650160 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1650160 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1650160 | pubmed:pagination | 529-41 | lld:pubmed |
| pubmed-article:1650160 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:meshHeading | pubmed-meshheading:1650160-... | lld:pubmed |
| pubmed-article:1650160 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1650160 | pubmed:articleTitle | Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy. | lld:pubmed |
| pubmed-article:1650160 | pubmed:affiliation | Department of Neurology, University of Michigan, Ann Arbor. | lld:pubmed |
| pubmed-article:1650160 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1650160 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1650160 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1650160 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1650160 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1650160 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1650160 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1650160 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1650160 | lld:pubmed |
