| pubmed-article:16500648 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16500648 | lifeskim:mentions | umls-concept:C0036111 | lld:lifeskim |
| pubmed-article:16500648 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:16500648 | lifeskim:mentions | umls-concept:C0021554 | lld:lifeskim |
| pubmed-article:16500648 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16500648 | lifeskim:mentions | umls-concept:C1136169 | lld:lifeskim |
| pubmed-article:16500648 | lifeskim:mentions | umls-concept:C0332291 | lld:lifeskim |
| pubmed-article:16500648 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16500648 | pubmed:dateCreated | 2006-3-17 | lld:pubmed |
| pubmed-article:16500648 | pubmed:abstractText | Studies [Zhou, D., Chen, L.-M., Hernandez, L., Shears, S.B., and Galán, J.E. (2001) A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host-cell actin cytoskeleton rearrangements and bacterial internalization. Mol. Microbiol. 39, 248-259] with engineered Salmonella mutants showed that deletion of SopE attenuated the pathogen's ability to deplete host-cell InsP5 and remodel the cytoskeleton. We pursued these observations: In SopE-transfected host-cells, membrane ruffling was induced, but SopE did not dephosphorylate InsP5, nor did it recruit PTEN (a cytosolic InsP5 phosphatase) for this task. However, PTEN strengthened SopE-mediated membrane ruffling. We conclude SopE promotes host-cell InsP5 hydrolysis only with the assistance of other Salmonella proteins. Our demonstration that Salmonella-mediated cytoskeletal modifications are independent of inositolphosphates will focus future studies on elucidating alternate pathogenic consequences of InsP5 metabolism, including ion channel conductance and apoptosis. | lld:pubmed |
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| pubmed-article:16500648 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16500648 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16500648 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16500648 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16500648 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16500648 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:16500648 | pubmed:author | pubmed-author:ShearsStephen... | lld:pubmed |
| pubmed-article:16500648 | pubmed:author | pubmed-author:ChoiKuicheonK | lld:pubmed |
| pubmed-article:16500648 | pubmed:author | pubmed-author:DeleuSandrine... | lld:pubmed |
| pubmed-article:16500648 | pubmed:author | pubmed-author:ReeceJeff MJM | lld:pubmed |
| pubmed-article:16500648 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16500648 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:16500648 | pubmed:volume | 580 | lld:pubmed |
| pubmed-article:16500648 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16500648 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16500648 | pubmed:pagination | 1709-15 | lld:pubmed |
| pubmed-article:16500648 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16500648 | pubmed:meshHeading | pubmed-meshheading:16500648... | lld:pubmed |
| pubmed-article:16500648 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16500648 | pubmed:articleTitle | Pathogenicity of Salmonella: SopE-mediated membrane ruffling is independent of inositol phosphate signals. | lld:pubmed |
| pubmed-article:16500648 | pubmed:affiliation | Inositol Signaling Section, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, NC 27709, USA. | lld:pubmed |
| pubmed-article:16500648 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16500648 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16500648 | lld:pubmed |
