Linked Life Data

16499603

Source:http://linkedlifedata.com/resource/pubmed/id/16499603

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pubmed-article:16499603pubmed:abstractTextMixed hematopoietic chimerism usually carries with it the tolerance to any other tissue from the same donor. Consequently, the establishment of a sustained chimerism may allow long-term acceptance of transplanted organs without immunosuppression. We report a girl with refractory severe aplastic anemia who developed low recipient level hematopoietic chimerism following transplantation of maternal highly purified CD34+ cells without prophylactic immunosuppression. Renal thrombotic microangiopathy led to chronic renal failure and she received skin allografts from her mother in view of a future kidney donation. The maternal skin grafts were accepted without immunosuppression and the hematopoietic chimerism remained stable. Skin transplantation may be a helpful and easily applicable tool to monitor donor-related tolerance in hematopoietic chimerism clinically. It should contribute to minimize the risks of subsequent solid organ transplantation from the same donor without immunosuppression.lld:pubmed
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pubmed-article:16499603pubmed:pagination128-31lld:pubmed
pubmed-article:16499603pubmed:dateRevised2006-10-31lld:pubmed
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pubmed-article:16499603pubmed:articleTitleSkin transplantation to monitor clinical donor-related tolerance in mixed hematopoietic chimerism.lld:pubmed
pubmed-article:16499603pubmed:affiliationDepartment of Pediatrics, Medical University Graz, Graz, Austria. christoph.mache@meduni-graz.atlld:pubmed
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