| pubmed-article:16497716 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C0237868 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C0206529 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C0036679 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:16497716 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:16497716 | pubmed:issue | Pt 1 | lld:pubmed |
| pubmed-article:16497716 | pubmed:dateCreated | 2006-5-16 | lld:pubmed |
| pubmed-article:16497716 | pubmed:abstractText | Type 1 metabotropic glutamate receptors (mGluR1) in Purkinje neurones (PNs) are important for motor learning and coordination. Here, two divergent mGluR1 Ca2+-signalling pathways and the associated membrane conductances were distinguished kinetically and pharmacologically after activation by 1-ms photorelease of L-glutamate or by bursts of parallel fibre (PF) stimulation. A new, mGluR1-mediated transient K+ conductance was seen prior to the slow EPSC (sEPSC). It was seen only in PNs previously allowed to fire spontaneously or held at depolarized potentials for several seconds and was slowly inhibited by agatoxin IVA, which blocks P/Q-type Ca2+ channels. It peaked in 148 ms, had well-defined kinetics and, unlike the sEPSC, was abolished by the phospholipase C (PLC) inhibitor U73122. It was blocked by the BK Ca2+-activated K+ channel blocker iberiotoxin and unaffected by apamin, indicating selective activation of BK channels by PLC-dependent store-released Ca2+. The K+ conductance and underlying transient Ca2+ release showed a highly reproducible delay of 99.5 ms following PF burst stimulation, with a precision of 1-2 ms in repeated responses of the same PN, and a subsequent fast rise and fall of Ca2+ concentration. Analysis of Ca2+ signals showed that activation of the K+ conductance by Ca2+ release occurred in small dendrites and subresolution structures, most probably spines. The results show that PF burst stimulation activates two pathways of mGluR1 signalling in PNs. First, transient, PLC-dependent Ca2+ release from stores with precisely reproducible timing and second, slower Ca2+ influx in the cation-permeable sEPSC channel. The priming by prior Ca2+ influx in P/Q-type Ca2+ channels may determine the path of mGluR1 signalling. The precise timing of PLC-mediated store release may be important for interactions of PF mGluR1 signalling with other inputs to the PN. | lld:pubmed |
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| pubmed-article:16497716 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16497716 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16497716 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16497716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16497716 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16497716 | pubmed:month | May | lld:pubmed |
| pubmed-article:16497716 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:16497716 | pubmed:author | pubmed-author:OgdenDavidD | lld:pubmed |
| pubmed-article:16497716 | pubmed:author | pubmed-author:CanepariMarco... | lld:pubmed |
| pubmed-article:16497716 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16497716 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16497716 | pubmed:volume | 573 | lld:pubmed |
| pubmed-article:16497716 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16497716 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16497716 | pubmed:pagination | 65-82 | lld:pubmed |
| pubmed-article:16497716 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16497716 | pubmed:meshHeading | pubmed-meshheading:16497716... | lld:pubmed |
