| pubmed-article:16492782 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16492782 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:16492782 | lifeskim:mentions | umls-concept:C0014467 | lld:lifeskim |
| pubmed-article:16492782 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:16492782 | lifeskim:mentions | umls-concept:C1327414 | lld:lifeskim |
| pubmed-article:16492782 | lifeskim:mentions | umls-concept:C0599896 | lld:lifeskim |
| pubmed-article:16492782 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:16492782 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:16492782 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:16492782 | pubmed:dateCreated | 2006-3-15 | lld:pubmed |
| pubmed-article:16492782 | pubmed:abstractText | Although leukocytes of the innate immune system, including eosinophils, contain within their granules preformed stores of cytokines available for selective and rapid release, little is known about the mechanisms governing the mobilization and secretion of these cytokines. Here we show that a cytokine receptor, the IL-4 receptor alpha chain, mediates eotaxin-stimulated mobilization of preformed IL-4 from eosinophil granules into secretory vesicles. Eosinophils contain substantial intracellular quantities of several granule- and vesicle-associated cytokine receptors, including IL-4, IL-6, and IL-13 receptors as well as CCR3. Both IL-4 and IL-4 receptor alpha chain colocalized in eosinophil granules; and after eotaxin-stimulation, IL-4 receptor alpha chain, bearing bound IL-4, was mobilized into secretory vesicles. These findings indicate that intracellular cytokine receptors within secretory vesicles transport their cognate cytokines requisite for the secretion of cytokines preformed in innate immune leukocytes. | lld:pubmed |
| pubmed-article:16492782 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16492782 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16492782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16492782 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16492782 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16492782 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:16492782 | pubmed:author | pubmed-author:WellerPeter... | lld:pubmed |
| pubmed-article:16492782 | pubmed:author | pubmed-author:DvorakAnn MAM | lld:pubmed |
| pubmed-article:16492782 | pubmed:author | pubmed-author:MeloRossana... | lld:pubmed |
| pubmed-article:16492782 | pubmed:author | pubmed-author:PerezSandra... | lld:pubmed |
| pubmed-article:16492782 | pubmed:author | pubmed-author:SpencerLisa... | lld:pubmed |
| pubmed-article:16492782 | pubmed:author | pubmed-author:BaffordStaci... | lld:pubmed |
| pubmed-article:16492782 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16492782 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:16492782 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:16492782 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16492782 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16492782 | pubmed:pagination | 3333-8 | lld:pubmed |
| pubmed-article:16492782 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
| pubmed-article:16492782 | pubmed:meshHeading | pubmed-meshheading:16492782... | lld:pubmed |
