| pubmed-article:16491077 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16491077 | lifeskim:mentions | umls-concept:C0282554 | lld:lifeskim |
| pubmed-article:16491077 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:16491077 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:16491077 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16491077 | pubmed:dateCreated | 2006-3-21 | lld:pubmed |
| pubmed-article:16491077 | pubmed:abstractText | The MyD88 adaptor protein is critical in Toll-like receptor and interleukin 1 receptor (IL-1R) signaling, but has not been linked to interferon-gamma receptor (IFN-gammaR) signaling. Here we demonstrate that MyD88 increased the half-life but not the synthesis of IFN-gamma-induced mRNA transcripts encoding tumor necrosis factor and IFN-gamma-inducible protein 10. IFN-gamma stimulation triggered a physical association between the IFN-gammaR1 and MyD88. Transcript stabilization required activation of mixed-lineage kinase 3 and p38 mitogen-activated protein kinase and the presence of an adenine-uridine-rich element in the transcript's 3' untranslated region. These results demonstrate a MyD88-dependent post-transcriptional mechanism through which IFN-gamma can enhance the expression of genes encoding proinflammatory molecules. | lld:pubmed |
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| pubmed-article:16491077 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16491077 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16491077 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16491077 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16491077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16491077 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16491077 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16491077 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:16491077 | pubmed:author | pubmed-author:SunDongxuD | lld:pubmed |
| pubmed-article:16491077 | pubmed:author | pubmed-author:DingAihaoA | lld:pubmed |
| pubmed-article:16491077 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16491077 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:16491077 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16491077 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16491077 | pubmed:pagination | 375-81 | lld:pubmed |
| pubmed-article:16491077 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:16491077 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16491077 | pubmed:articleTitle | MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA. | lld:pubmed |
| pubmed-article:16491077 | pubmed:affiliation | Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA. | lld:pubmed |
| pubmed-article:16491077 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16491077 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16491077 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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