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pubmed-article:16490123pubmed:abstractTextWe systematically reviewed the current understanding of human population immunity against SARS-CoV in different groups, settings and geography. Our meta-analysis, which included all identified studies except those on wild animal handlers, yielded an overall seroprevalence of 0.10% [95% confidence interval (CI) 0.02-0.18]. Health-care workers and others who had close contact with SARS patients had a slightly higher degree of seroconversion (0.23%, 95% CI 0.02-0.45) compared to healthy blood donors, others from the general community or non-SARS patients recruited from the health-care setting (0.16%, 95% CI 0-0.37). When analysed by the two broad classes of testing procedures, it is clear that serial confirmatory test protocols resulted in a much lower estimate (0.050%, 95% CI 0-0.15) than single test protocols (0.20%, 95% CI 0.06-0.34). Potential epidemiological and laboratory pitfalls are also discussed as they may give rise to false or inconsistent results in measuring the seroprevalence of IgG antibodies to SARS-CoV.lld:pubmed
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pubmed-article:16490123pubmed:authorpubmed-author:FraserCClld:pubmed
pubmed-article:16490123pubmed:authorpubmed-author:HedleyA JAJlld:pubmed
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pubmed-article:16490123pubmed:authorpubmed-author:MinX TXTlld:pubmed
pubmed-article:16490123pubmed:authorpubmed-author:FergusonN MNMlld:pubmed
pubmed-article:16490123pubmed:authorpubmed-author:GhaniA CAClld:pubmed
pubmed-article:16490123pubmed:authorpubmed-author:LeungG MGMlld:pubmed
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pubmed-article:16490123pubmed:volume134lld:pubmed
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pubmed-article:16490123pubmed:pagination211-21lld:pubmed
pubmed-article:16490123pubmed:dateRevised2010-9-14lld:pubmed
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pubmed-article:16490123pubmed:articleTitleSeroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups.lld:pubmed
pubmed-article:16490123pubmed:affiliationDepartment of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, ChinaTakemi Program, Harvard School of Public Health, Boston, MA, USA. gmleung@hkucc.hklld:pubmed
pubmed-article:16490123pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16490123pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:16490123pubmed:publicationTypeMeta-Analysislld:pubmed
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