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pubmed-article:16485139pubmed:abstractTextThis study was conducted to evaluate the effects of ghrelin on insulin's capacity to suppress endogenous glucose production and promote glucose disposal in mice. To establish whether the growth hormone secretagogue (GHS) receptor can mediate the putative effect of ghrelin on the action of insulin, we also determined the metabolic effects of growth hormone releasing peptide 6 (GHRP-6), a specific GHS receptor agonist. In addition, we explored the biological significance of des-ghrelin (unacylated ghrelin) in this experimental context.lld:pubmed
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pubmed-article:16485139pubmed:articleTitleGhrelin differentially affects hepatic and peripheral insulin sensitivity in mice.lld:pubmed
pubmed-article:16485139pubmed:affiliationDepartment of Endocrinology and Metabolic Diseases, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. a.c.heijboer@lumc.nllld:pubmed
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