| pubmed-article:16481464 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16481464 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16481464 | lifeskim:mentions | umls-concept:C1413614 | lld:lifeskim |
| pubmed-article:16481464 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:16481464 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:16481464 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16481464 | pubmed:dateCreated | 2006-3-2 | lld:pubmed |
| pubmed-article:16481464 | pubmed:abstractText | The members of the E2F family of transcription factors are key regulators of genes involved in cell cycle progression, cell fate determination, DNA damage repair, and apoptosis. Many cell-based experiments suggest that E2F1 is a stronger inducer of apoptosis than the other E2Fs. Our previous work identified the E2F1 marked box and flanking region as critical for the specificity in E2F1 apoptosis induction. We have now used a yeast two-hybrid screen to identify proteins that bind the E2F1 marked box and flanking regions, with a potential role in E2F1 apoptosis induction. We identified Jab1 as an E2F1-specific binding protein and showed that Jab1 and E2F1 coexpression synergistically induce apoptosis, coincident with an induction of p53 protein accumulation. In contrast, Jab1 does not synergize with E2F1 to promote cell cycle entry. Cells depleted of Jab1 are deficient for both E2F1-induced apoptosis and induction of p53 accumulation. We suggest that Jab1 is an essential cofactor for the apoptotic function of E2F1. | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16481464 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16481464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16481464 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16481464 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16481464 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:16481464 | pubmed:author | pubmed-author:NevinsJoseph... | lld:pubmed |
| pubmed-article:16481464 | pubmed:author | pubmed-author:HallstromTimo... | lld:pubmed |
| pubmed-article:16481464 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16481464 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16481464 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:16481464 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16481464 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16481464 | pubmed:pagination | 613-23 | lld:pubmed |
| pubmed-article:16481464 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:meshHeading | pubmed-meshheading:16481464... | lld:pubmed |
| pubmed-article:16481464 | pubmed:year | 2006 | lld:pubmed |
