| pubmed-article:16480768 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16480768 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:16480768 | lifeskim:mentions | umls-concept:C0013268 | lld:lifeskim |
| pubmed-article:16480768 | lifeskim:mentions | umls-concept:C1260943 | lld:lifeskim |
| pubmed-article:16480768 | lifeskim:mentions | umls-concept:C0021017 | lld:lifeskim |
| pubmed-article:16480768 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:16480768 | lifeskim:mentions | umls-concept:C0015295 | lld:lifeskim |
| pubmed-article:16480768 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:16480768 | lifeskim:mentions | umls-concept:C0206071 | lld:lifeskim |
| pubmed-article:16480768 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16480768 | pubmed:dateCreated | 2006-3-13 | lld:pubmed |
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| pubmed-article:16480768 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16480768 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16480768 | pubmed:abstractText | Immunoglobulin class switching is characteristic to the tetrapod lineage, but the nature of this process has been elucidated only in mammals, where I-exon transcription initiates and directs the recombination in the IgH locus. Here, it is shown that an I-exon occurs 5' of the nu (IgY constant region) gene of the duck (Anas platyrhynchos): it is longer than mammalian I-exons and comprised primarily of tandem repeats. The Inu promoter was identified and shown to be responsive to stimulation with IL-4 but not LPS. It contains Oct, LYF-1, ATF, and C/EBP motifs. Site directed mutagenesis indicates that 2 C/EBP motifs are uniquely necessary for the response of the promoter to IL-4, as tested in the mouse pre-B cell line, 70Z/3. These results support the conclusion that the signal transduction pathways controlling I-exon promoter responses to cytokines have been highly conserved in vertebrate evolution. | lld:pubmed |
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| pubmed-article:16480768 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16480768 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16480768 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16480768 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16480768 | pubmed:issn | 0145-305X | lld:pubmed |
| pubmed-article:16480768 | pubmed:author | pubmed-author:ChapmanRobert... | lld:pubmed |
| pubmed-article:16480768 | pubmed:author | pubmed-author:LundqvistMats... | lld:pubmed |
| pubmed-article:16480768 | pubmed:author | pubmed-author:MiddletonDarl... | lld:pubmed |
| pubmed-article:16480768 | pubmed:author | pubmed-author:WarrGregory... | lld:pubmed |
| pubmed-article:16480768 | pubmed:author | pubmed-author:McElveenBryan... | lld:pubmed |
| pubmed-article:16480768 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16480768 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:16480768 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16480768 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16480768 | pubmed:pagination | 575-87 | lld:pubmed |
| pubmed-article:16480768 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16480768 | pubmed:meshHeading | pubmed-meshheading:16480768... | lld:pubmed |
| pubmed-article:16480768 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16480768 | pubmed:articleTitle | Evolution of antibody class switching: identification and transcriptional control of an Inu exon in the duck (Anas platyrhynchos). | lld:pubmed |
| pubmed-article:16480768 | pubmed:affiliation | Marine Biomedicine and Environmental Sciences Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 331 Fort Johnson Road, Charleston, SC 29412, USA. lundquml@musc.edu | lld:pubmed |
