| pubmed-article:16479148 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16479148 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16479148 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16479148 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:16479148 | lifeskim:mentions | umls-concept:C0003483 | lld:lifeskim |
| pubmed-article:16479148 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16479148 | lifeskim:mentions | umls-concept:C1872431 | lld:lifeskim |
| pubmed-article:16479148 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16479148 | pubmed:dateCreated | 2006-4-13 | lld:pubmed |
| pubmed-article:16479148 | pubmed:abstractText | Isosteviol is a derivative of stevioside, a constituent of Stevia rebaudiana, which is commonly used as a noncaloric sugar substitute in Japan and Brazil. The aims of this study were to examine whether isosteviol alters angiotensin-II-induced cell proliferation in rat aortic smooth muscle cells. Cultured rat aortic smooth muscle cells were preincubated with isosteviol, then stimulated with angiotensin II, after which [(3)H]thymidine incorporation and endothelin-1 secretion were examined. Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 2'7'-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive oxygen species generated by the effects of angiotensin II. The inductive properties of angiotensin II on extracellular signal-regulated kinase (ERK) phosphorylation were found reversed with isosteviol and antioxidants such as N-acetylcysteine. In summary, we speculate that isosteviol inhibits angiotensin-II-induced cell proliferation and endothelin-1 secretion via attenuation of reactive oxygen species generation. Thus, this study provides important insights that may contribute to the effects of isosteviol on the cardiovascular system. | lld:pubmed |
| pubmed-article:16479148 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16479148 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16479148 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16479148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16479148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16479148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16479148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16479148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16479148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16479148 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16479148 | pubmed:issn | 0031-7012 | lld:pubmed |
| pubmed-article:16479148 | pubmed:author | pubmed-author:LinJaung-Geng... | lld:pubmed |
| pubmed-article:16479148 | pubmed:author | pubmed-author:ChiuWen-TaWT | lld:pubmed |
| pubmed-article:16479148 | pubmed:author | pubmed-author:LiuJu-ChiJC | lld:pubmed |
| pubmed-article:16479148 | pubmed:author | pubmed-author:LohShih-Hurng... | lld:pubmed |
| pubmed-article:16479148 | pubmed:author | pubmed-author:ChengTzu-Hurn... | lld:pubmed |
| pubmed-article:16479148 | pubmed:author | pubmed-author:ChenCheng-Hsi... | lld:pubmed |
| pubmed-article:16479148 | pubmed:author | pubmed-author:WongKar-LokKL | lld:pubmed |
| pubmed-article:16479148 | pubmed:author | pubmed-author:HongHong-JyeH... | lld:pubmed |
| pubmed-article:16479148 | pubmed:author | pubmed-author:YangHung-YuHY | lld:pubmed |
| pubmed-article:16479148 | pubmed:author | pubmed-author:LinJia-WeiJW | lld:pubmed |
| pubmed-article:16479148 | pubmed:author | pubmed-author:KaoPei-FengPF | lld:pubmed |
| pubmed-article:16479148 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16479148 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:16479148 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16479148 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16479148 | pubmed:pagination | 163-9 | lld:pubmed |
| pubmed-article:16479148 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:meshHeading | pubmed-meshheading:16479148... | lld:pubmed |
| pubmed-article:16479148 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16479148 | pubmed:articleTitle | Antiproliferative effect of isosteviol on angiotensin-II-treated rat aortic smooth muscle cells. | lld:pubmed |
| pubmed-article:16479148 | pubmed:affiliation | Department of Anesthesia, China Medical University and Hospital, Taichung, Taiwan, ROC. | lld:pubmed |
| pubmed-article:16479148 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16479148 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
