| pubmed-article:1647816 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1647816 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1647816 | lifeskim:mentions | umls-concept:C0034802 | lld:lifeskim |
| pubmed-article:1647816 | lifeskim:mentions | umls-concept:C0425245 | lld:lifeskim |
| pubmed-article:1647816 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:1647816 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:1647816 | pubmed:dateCreated | 1991-8-2 | lld:pubmed |
| pubmed-article:1647816 | pubmed:abstractText | The rotational diffusion of epidermal growth factor (EGF) bound to its specific receptor on the surface of human carcinoma A431 cells was studied by means of time-resolved phosphorescence anisotropy measurements. The rotational mobility was measured on the total population of EGF receptors by using a saturating concentration of EGF conjugated with a phosphorescent label, erythrosin, or on the subpopulation of high-affinity EGF receptors by using a low concentration of labeled EGF. At 4 degrees C, the rotational correlation times for both the high-affinity and total (mostly low affinity) receptor populations were in the range of 60-100 microns. Elevation of the temperature to 37 degrees C resulted in a lengthening of the rotational correlation time of the total receptor population to 200-300 microns, confirming a previous study of receptor microaggregation. The high-affinity EGF receptors were completely immobilized at 37 degrees C (rotational correlation time greater than 500 microns). The data are consistent with a model involving association of the cytoskeleton with the high-affinity receptors at 37 degrees C, but not at 4 degrees C. | lld:pubmed |
| pubmed-article:1647816 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1647816 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1647816 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1647816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1647816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1647816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1647816 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1647816 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1647816 | pubmed:issn | 0006-2960 | lld:pubmed |
| pubmed-article:1647816 | pubmed:author | pubmed-author:JohnsonD ADA | lld:pubmed |
| pubmed-article:1647816 | pubmed:author | pubmed-author:JovinT MTM | lld:pubmed |
| pubmed-article:1647816 | pubmed:author | pubmed-author:Arndt-JovinD... | lld:pubmed |
| pubmed-article:1647816 | pubmed:author | pubmed-author:ZidovetzkiRR | lld:pubmed |
| pubmed-article:1647816 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1647816 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:1647816 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:1647816 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1647816 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1647816 | pubmed:pagination | 6162-6 | lld:pubmed |
| pubmed-article:1647816 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:1647816 | pubmed:meshHeading | pubmed-meshheading:1647816-... | lld:pubmed |
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| pubmed-article:1647816 | pubmed:meshHeading | pubmed-meshheading:1647816-... | lld:pubmed |
| pubmed-article:1647816 | pubmed:meshHeading | pubmed-meshheading:1647816-... | lld:pubmed |
| pubmed-article:1647816 | pubmed:meshHeading | pubmed-meshheading:1647816-... | lld:pubmed |
| pubmed-article:1647816 | pubmed:meshHeading | pubmed-meshheading:1647816-... | lld:pubmed |
| pubmed-article:1647816 | pubmed:meshHeading | pubmed-meshheading:1647816-... | lld:pubmed |
| pubmed-article:1647816 | pubmed:meshHeading | pubmed-meshheading:1647816-... | lld:pubmed |
| pubmed-article:1647816 | pubmed:meshHeading | pubmed-meshheading:1647816-... | lld:pubmed |
| pubmed-article:1647816 | pubmed:meshHeading | pubmed-meshheading:1647816-... | lld:pubmed |
| pubmed-article:1647816 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1647816 | pubmed:articleTitle | Rotational mobility of high-affinity epidermal growth factor receptors on the surface of living A431 cells. | lld:pubmed |
| pubmed-article:1647816 | pubmed:affiliation | Department of Biology, University of California, Riverside 92521. | lld:pubmed |
| pubmed-article:1647816 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1647816 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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