| pubmed-article:16476743 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C0148323 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C0017978 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C1425345 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C0205197 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:16476743 | lifeskim:mentions | umls-concept:C0450724 | lld:lifeskim |
| pubmed-article:16476743 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:16476743 | pubmed:dateCreated | 2006-4-10 | lld:pubmed |
| pubmed-article:16476743 | pubmed:abstractText | To examine whether globotriaosylceramide (Gb3/CD77) is a receptor for verotoxins (VTs) in vivo, sensitivity of Gb3/CD77 synthase null mutant mice to VT-2 and VT-1 was analyzed. Although wild-type mice died after administration of 0.02 microg of VT-2 or 1.0 microg of VT-1, the mutant mice showed no reaction to doses as much as 100 times that administered to wild types. Expression analysis of Gb3/CD77 in mouse tissues with antibody revealed that low, but definite, levels of Gb3/CD77 were expressed in the microvascular endothelial cells of the brain cortex and pia mater and in renal tubular capillaries. Corresponding to the Gb3/CD77 expression, tissue damage with edema, congestion, and cytopathic changes was observed, indicating that Gb3/CD77 (and its derivatives) exclusively function as a receptor for VTs in vivo. The lethal kinetics were similar regardless of lipopolysaccharide elimination in VT preparation, suggesting that basal Gb3/CD77 levels are sufficient for lethal effects of VTs. | lld:pubmed |
| pubmed-article:16476743 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16476743 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16476743 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16476743 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16476743 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:16476743 | pubmed:author | pubmed-author:FurukawaKeiko... | lld:pubmed |
| pubmed-article:16476743 | pubmed:author | pubmed-author:FurukawaKoich... | lld:pubmed |
| pubmed-article:16476743 | pubmed:author | pubmed-author:UranoTakeshiT | lld:pubmed |
| pubmed-article:16476743 | pubmed:author | pubmed-author:OhtaMichioM | lld:pubmed |
| pubmed-article:16476743 | pubmed:author | pubmed-author:WielsJoelleJ | lld:pubmed |
| pubmed-article:16476743 | pubmed:author | pubmed-author:ItoMasafumiM | lld:pubmed |
| pubmed-article:16476743 | pubmed:author | pubmed-author:OkudaTetsuyaT | lld:pubmed |
| pubmed-article:16476743 | pubmed:author | pubmed-author:TokudaNoriyoN | lld:pubmed |
| pubmed-article:16476743 | pubmed:author | pubmed-author:TajimaOrieO | lld:pubmed |
| pubmed-article:16476743 | pubmed:author | pubmed-author:KawamuraKumik... | lld:pubmed |
| pubmed-article:16476743 | pubmed:author | pubmed-author:NumataShin-ic... | lld:pubmed |
| pubmed-article:16476743 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16476743 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:16476743 | pubmed:volume | 281 | lld:pubmed |
| pubmed-article:16476743 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16476743 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16476743 | pubmed:pagination | 10230-5 | lld:pubmed |
| pubmed-article:16476743 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16476743 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16476743 | pubmed:articleTitle | Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. | lld:pubmed |
| pubmed-article:16476743 | pubmed:affiliation | Department of Biochemistry II, Nagoya University School of Medicine, Tsurumai, Showa-ku, Nagoya 466-0065, Japan. | lld:pubmed |
| pubmed-article:16476743 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16476743 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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