| pubmed-article:16474399 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16474399 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:16474399 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:16474399 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:16474399 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:16474399 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16474399 | lifeskim:mentions | umls-concept:C0079613 | lld:lifeskim |
| pubmed-article:16474399 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:16474399 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:16474399 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:16474399 | lifeskim:mentions | umls-concept:C0443211 | lld:lifeskim |
| pubmed-article:16474399 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16474399 | pubmed:dateCreated | 2006-3-7 | lld:pubmed |
| pubmed-article:16474399 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16474399 | pubmed:abstractText | CD8+ T cells can mediate eradication of established tumors, and strategies to amplify tumor-reactive T-cell numbers by immunization or ex vivo expansion followed by adoptive transfer are currently being explored in individuals with cancer. Generating effective CD8+ T cell-mediated responses to tumors is often impeded by T-cell tolerance to relevant tumor antigens, as most of these antigens are also expressed in normal tissues. We examined whether such tolerant T cells could be rescued and functionally restored for use in therapy of established tumors. We used a transgenic T-cell receptor (TCR) mouse model in which peripheral CD8+ T cells specific for a candidate tumor antigen also expressed in liver are tolerant, failing to proliferate or secrete interleukin (IL)-2 in response to antigen. Molecular and cellular analysis showed that these tolerant T cells expressed the IL-15 receptor alpha chain, and could be induced to proliferate in vitro in response to exogenous IL-15. Such proliferation abrogated tolerance and the rescued cells became effective in treating leukemia. Therefore, high-affinity CD8+ T cells are not necessarily deleted by encounter with self-antigen in the periphery, and can potentially be rescued and expanded for use in tumor immunotherapy. | lld:pubmed |
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| pubmed-article:16474399 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16474399 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16474399 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16474399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16474399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16474399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16474399 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16474399 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16474399 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:16474399 | pubmed:author | pubmed-author:MorimotoJunko... | lld:pubmed |
| pubmed-article:16474399 | pubmed:author | pubmed-author:OhlénClaesC | lld:pubmed |
| pubmed-article:16474399 | pubmed:author | pubmed-author:GreenbergPhil... | lld:pubmed |
| pubmed-article:16474399 | pubmed:author | pubmed-author:CookeMichael... | lld:pubmed |
| pubmed-article:16474399 | pubmed:author | pubmed-author:SatherBlythe... | lld:pubmed |
| pubmed-article:16474399 | pubmed:author | pubmed-author:DossettMichel... | lld:pubmed |
| pubmed-article:16474399 | pubmed:author | pubmed-author:TeagueRyan... | lld:pubmed |
| pubmed-article:16474399 | pubmed:author | pubmed-author:SuttonSusan... | lld:pubmed |
| pubmed-article:16474399 | pubmed:author | pubmed-author:SacksJilian... | lld:pubmed |
| pubmed-article:16474399 | pubmed:author | pubmed-author:HuangMaria... | lld:pubmed |
| pubmed-article:16474399 | pubmed:author | pubmed-author:TanXiaoxioX | lld:pubmed |
| pubmed-article:16474399 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16474399 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:16474399 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16474399 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16474399 | pubmed:pagination | 335-41 | lld:pubmed |
| pubmed-article:16474399 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16474399 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16474399 | pubmed:articleTitle | Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors. | lld:pubmed |
| pubmed-article:16474399 | pubmed:affiliation | Department of Immunology, University of Washington School of Medicine, Office H-564 HSC, Box 357650, Seattle, Washington 98195, USA. | lld:pubmed |
| pubmed-article:16474399 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16474399 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16474399 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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