| pubmed-article:1647335 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1647335 | lifeskim:mentions | umls-concept:C0019185 | lld:lifeskim |
| pubmed-article:1647335 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:1647335 | lifeskim:mentions | umls-concept:C0011849 | lld:lifeskim |
| pubmed-article:1647335 | lifeskim:mentions | umls-concept:C0085243 | lld:lifeskim |
| pubmed-article:1647335 | lifeskim:mentions | umls-concept:C0205322 | lld:lifeskim |
| pubmed-article:1647335 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:1647335 | lifeskim:mentions | umls-concept:C0021149 | lld:lifeskim |
| pubmed-article:1647335 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1647335 | pubmed:dateCreated | 1991-7-31 | lld:pubmed |
| pubmed-article:1647335 | pubmed:abstractText | The frequency of diabetes mellitus was compared in non-obese diabetic mice before and after inadvertent exposure of the colony to mouse hepatitis virus infection. Prior to exposure, diabetes prevalence and cumulative diabetes incidence in 7-month-old mice was 65% and 25% in females and males, respectively. Diabetes incidence/quarter revealed a seasonal pattern with peaks in winter. After mouse hepatitis exposure, the diabetes incidence in the colony decreased and testing for mouse hepatitis antibody in blood samples revealed a persistent infection. In the offspring of mice delivered by caesarean section, the diabetic incidence increased sharply from a nadir of 36% to 95% and from 9% to 65% in females and males, respectively. In individual mice, diabetes resistance was strongly correlated to high titres of mouse hepatitis virus antibody. The results of this inadvertent viral infection demonstrate that a diabetes-susceptible genotype is strongly modulated by environmental factors. Investigators studying this diabetes model should strive for specific pathogen-free colony status and a high incidence of diabetes before attempting to investigate therapeutic modalities. | lld:pubmed |
| pubmed-article:1647335 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1647335 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1647335 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1647335 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1647335 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1647335 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:1647335 | pubmed:author | pubmed-author:HerbergLL | lld:pubmed |
| pubmed-article:1647335 | pubmed:author | pubmed-author:PartkeH JHJ | lld:pubmed |
| pubmed-article:1647335 | pubmed:author | pubmed-author:Dagnaes-Hanse... | lld:pubmed |
| pubmed-article:1647335 | pubmed:author | pubmed-author:WilberzSS | lld:pubmed |
| pubmed-article:1647335 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1647335 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:1647335 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1647335 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1647335 | pubmed:pagination | 2-5 | lld:pubmed |
| pubmed-article:1647335 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1647335 | pubmed:meshHeading | pubmed-meshheading:1647335-... | lld:pubmed |
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| pubmed-article:1647335 | pubmed:meshHeading | pubmed-meshheading:1647335-... | lld:pubmed |
| pubmed-article:1647335 | pubmed:meshHeading | pubmed-meshheading:1647335-... | lld:pubmed |
| pubmed-article:1647335 | pubmed:meshHeading | pubmed-meshheading:1647335-... | lld:pubmed |
| pubmed-article:1647335 | pubmed:meshHeading | pubmed-meshheading:1647335-... | lld:pubmed |
| pubmed-article:1647335 | pubmed:meshHeading | pubmed-meshheading:1647335-... | lld:pubmed |
| pubmed-article:1647335 | pubmed:meshHeading | pubmed-meshheading:1647335-... | lld:pubmed |
| pubmed-article:1647335 | pubmed:meshHeading | pubmed-meshheading:1647335-... | lld:pubmed |
| pubmed-article:1647335 | pubmed:meshHeading | pubmed-meshheading:1647335-... | lld:pubmed |
| pubmed-article:1647335 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1647335 | pubmed:articleTitle | Persistent MHV (mouse hepatitis virus) infection reduces the incidence of diabetes mellitus in non-obese diabetic mice. | lld:pubmed |
| pubmed-article:1647335 | pubmed:affiliation | Diabetes Forschungsinstitut, Universität Düsseldorf, FRG. | lld:pubmed |
| pubmed-article:1647335 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1647335 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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