| pubmed-article:1646420 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1646420 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:1646420 | lifeskim:mentions | umls-concept:C0039663 | lld:lifeskim |
| pubmed-article:1646420 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1646420 | lifeskim:mentions | umls-concept:C0007370 | lld:lifeskim |
| pubmed-article:1646420 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:1646420 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
| pubmed-article:1646420 | lifeskim:mentions | umls-concept:C1706089 | lld:lifeskim |
| pubmed-article:1646420 | lifeskim:mentions | umls-concept:C0599668 | lld:lifeskim |
| pubmed-article:1646420 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1646420 | pubmed:dateCreated | 1991-7-17 | lld:pubmed |
| pubmed-article:1646420 | pubmed:abstractText | In experiments in which mice were placed with their forepaws over a 4 cm high horizontal bar, delta-9-tetrahydrocannabinol (THC; 10 mg/kg i.p.) delayed descent from the bar. This effect on descent latency was markedly enhanced by physostigmine (0.05 or 0.25 mg/kg s.c.) and oxotremorine (0.04 or 0.08 mg/kg s.c.), administered immediately before THC. These interactions were attenuated by atropine (2.0 mg/kg s.c.) and (-)-scopolamine (1.9 mg/kg s.c.) but not by atropine methyl nitrate (2.11 mg/kg s.c.), which does not readily cross the blood-brain barrier. However, atropine methyl nitrate did prevent salivation induced by oxotremorine in the presence of THC. No synergism was detected between THC and neostigmine (0.047 mg/kg s.c.). Atropine and (-)-scopolamine also decreased the ability of chlordiazepoxide (10 mg/kg s.c.) to enhance the effect of THC on descent latency. The interaction was not antagonized by atropine methyl nitrate or mecamylamine (1.17 or 2.34 mg/kg s.c.). These results point to an involvement of central acetylcholine-releasing pathways in the cataleptic response of mice to THC. | lld:pubmed |
| pubmed-article:1646420 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1646420 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646420 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1646420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646420 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1646420 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1646420 | pubmed:issn | 0028-3908 | lld:pubmed |
| pubmed-article:1646420 | pubmed:author | pubmed-author:PertweeR GRG | lld:pubmed |
| pubmed-article:1646420 | pubmed:author | pubmed-author:RossT MTM | lld:pubmed |
| pubmed-article:1646420 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1646420 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:1646420 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1646420 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1646420 | pubmed:pagination | 67-71 | lld:pubmed |
| pubmed-article:1646420 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:meshHeading | pubmed-meshheading:1646420-... | lld:pubmed |
| pubmed-article:1646420 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1646420 | pubmed:articleTitle | Drugs which stimulate or facilitate central cholinergic transmission interact synergistically with delta-9-tetrahydrocannabinol to produce marked catalepsy in mice. | lld:pubmed |
| pubmed-article:1646420 | pubmed:affiliation | Division of Pharmacology, Marischal College, University of Aberdeen, U.K. | lld:pubmed |
| pubmed-article:1646420 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1646420 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1646420 | lld:pubmed |
