Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16461922rdf:typepubmed:Citationlld:pubmed
pubmed-article:16461922lifeskim:mentionsumls-concept:C0037663lld:lifeskim
pubmed-article:16461922lifeskim:mentionsumls-concept:C0441472lld:lifeskim
pubmed-article:16461922lifeskim:mentionsumls-concept:C0233820lld:lifeskim
pubmed-article:16461922pubmed:issue1lld:pubmed
pubmed-article:16461922pubmed:dateCreated2006-2-7lld:pubmed
pubmed-article:16461922pubmed:abstractTextIt has been 75 years since Evans and Long identified a somatic growth-promoting substance in pituitary extracts, yet it is only in the last 20 years that the molecular basis for this action has been established. Three key elements in this elucidation were the cloning of the GH receptor, the identification of Janus kinase (JAK) 2 as the receptor-associated tyrosine kinase, and the delineation of signal transduction and activators of transcription (STAT) 5a/b as the key transcription factor(s) activated by JAK2. The interaction between these three elements results in enhanced postnatal growth and is the subject of this review. We describe a new model for GH receptor activation based on subunit rotation within a constitutive dimer, together with the phenotype and hepatic transcript profile of mice with targeted knockins to the receptor cytoplasmic domain. These support a central role for STAT5a/b in postnatal growth.lld:pubmed
pubmed-article:16461922pubmed:languageenglld:pubmed
pubmed-article:16461922pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16461922pubmed:citationSubsetIMlld:pubmed
pubmed-article:16461922pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16461922pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16461922pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16461922pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16461922pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16461922pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16461922pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16461922pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16461922pubmed:statusMEDLINElld:pubmed
pubmed-article:16461922pubmed:monthFeblld:pubmed
pubmed-article:16461922pubmed:issn0952-5041lld:pubmed
pubmed-article:16461922pubmed:authorpubmed-author:WatersM JMJlld:pubmed
pubmed-article:16461922pubmed:authorpubmed-author:BrownR JRJlld:pubmed
pubmed-article:16461922pubmed:authorpubmed-author:FairlieD PDPlld:pubmed
pubmed-article:16461922pubmed:authorpubmed-author:HoangH NHNlld:pubmed
pubmed-article:16461922pubmed:authorpubmed-author:PelekanosR...lld:pubmed
pubmed-article:16461922pubmed:issnTypePrintlld:pubmed
pubmed-article:16461922pubmed:volume36lld:pubmed
pubmed-article:16461922pubmed:ownerNLMlld:pubmed
pubmed-article:16461922pubmed:authorsCompleteYlld:pubmed
pubmed-article:16461922pubmed:pagination1-7lld:pubmed
pubmed-article:16461922pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:meshHeadingpubmed-meshheading:16461922...lld:pubmed
pubmed-article:16461922pubmed:year2006lld:pubmed
pubmed-article:16461922pubmed:articleTitleNew insights into growth hormone action.lld:pubmed
pubmed-article:16461922pubmed:affiliationInstitute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland, St Lucia, Australia 4072. m.waters@imb.uq.edu.aulld:pubmed
pubmed-article:16461922pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16461922pubmed:publicationTypeReviewlld:pubmed
pubmed-article:16461922pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16461922lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16461922lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16461922lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16461922lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16461922lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16461922lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16461922lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16461922lld:pubmed