| pubmed-article:16461460 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16461460 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16461460 | lifeskim:mentions | umls-concept:C0280100 | lld:lifeskim |
| pubmed-article:16461460 | lifeskim:mentions | umls-concept:C1101610 | lld:lifeskim |
| pubmed-article:16461460 | lifeskim:mentions | umls-concept:C0919437 | lld:lifeskim |
| pubmed-article:16461460 | lifeskim:mentions | umls-concept:C1513400 | lld:lifeskim |
| pubmed-article:16461460 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:16461460 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16461460 | pubmed:dateCreated | 2006-2-15 | lld:pubmed |
| pubmed-article:16461460 | pubmed:abstractText | Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, and pancreatic tumors, we identified a solid cancer miRNA signature composed by a large portion of overexpressed miRNAs. Among these miRNAs are some with well characterized cancer association, such as miR-17-5p, miR-20a, miR-21, miR-92, miR-106a, and miR-155. The predicted targets for the differentially expressed miRNAs are significantly enriched for protein-coding tumor suppressors and oncogenes (P < 0.0001). A number of the predicted targets, including the tumor suppressors RB1 (Retinoblastoma 1) and TGFBR2 (transforming growth factor, beta receptor II) genes were confirmed experimentally. Our results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes. | lld:pubmed |
| pubmed-article:16461460 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16461460 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16461460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16461460 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16461460 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16461460 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:LiuChang-Gong... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:NegriniMassim... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:HarrisCurtis... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:CroceCarlo... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:ScarpaAldoA | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:VoliniaStefan... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:VecchioneAndr... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:CalinGeorge... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:CimminoAmelia... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:VisoneRosaR | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:LanzaGiovanni... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:FerracinManue... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:RoldoClaudiaC | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:AmbsStefanS | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:PetroccaFabio... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:IorioMarilena... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:PrueittRobyn... | lld:pubmed |
| pubmed-article:16461460 | pubmed:author | pubmed-author:YanaiharaNozu... | lld:pubmed |
| pubmed-article:16461460 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16461460 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:16461460 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:16461460 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16461460 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16461460 | pubmed:pagination | 2257-61 | lld:pubmed |
| pubmed-article:16461460 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16461460 | pubmed:meshHeading | pubmed-meshheading:16461460... | lld:pubmed |
| pubmed-article:16461460 | pubmed:meshHeading | pubmed-meshheading:16461460... | lld:pubmed |
| pubmed-article:16461460 | pubmed:meshHeading | pubmed-meshheading:16461460... | lld:pubmed |
| pubmed-article:16461460 | pubmed:meshHeading | pubmed-meshheading:16461460... | lld:pubmed |
| pubmed-article:16461460 | pubmed:meshHeading | pubmed-meshheading:16461460... | lld:pubmed |
| pubmed-article:16461460 | pubmed:meshHeading | pubmed-meshheading:16461460... | lld:pubmed |
| pubmed-article:16461460 | pubmed:meshHeading | pubmed-meshheading:16461460... | lld:pubmed |
| pubmed-article:16461460 | pubmed:meshHeading | pubmed-meshheading:16461460... | lld:pubmed |
| pubmed-article:16461460 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16461460 | pubmed:articleTitle | A microRNA expression signature of human solid tumors defines cancer gene targets. | lld:pubmed |
| pubmed-article:16461460 | pubmed:affiliation | Department of Molecular Virology, Immunology, and Medical Genetics and Cancer Comprehensive Center, Ohio State University, Columbus, OH 43210, USA. | lld:pubmed |
| pubmed-article:16461460 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16461460 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16461460 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16461460 | lld:pubmed |
