Linked Life Data

16460885

Source:http://linkedlifedata.com/resource/pubmed/id/16460885

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pubmed-article:16460885pubmed:abstractTextThe inflammatory balance modulated by pro- and anti-inflammatory cytokines in atherosclerotic lesions is still unclear. The purpose of this study was to investigate the immunohistochemical localization of interleukin-10 (IL-10) and the topographical correlation between IL-10-positive cells and the other inflammatory cells in human coronary arteries. Coronary arteries (242 sections) were obtained from 43 Japanese patients (mean age: 72+/-14 years) at autopsy, and the intimal changes were classified according to the classification of the American Heart Association. The immunohistochemical distributions of IL-10, oxidized low-density lipoprotein (oxLDL), macrophages, and lymphocytes were examined morphometrically. We compared the ratios of IL-10-positive cells/macrophages and T-lymphocyte number among the shoulder and in other areas of type IV lesions and in atherosclerotic lesion types. IL-10 was expressed mainly by macrophages, and the positive cell number increased as the lesions became advanced (p<0.0001). The number of IL-10-positive cells was positively correlated with that of oxLDL-positive cells, and inversely with infiltrating T-lymphocytes (p<0.01). IL-10 expression in type IV-plaque shoulder was significantly lower than that in fibrous cap and the deeper portion under necrotic core (p<0.01). These findings suggest that IL-10 expression, seen mainly in macrophages, was possibly upregulated with oxLDL, and was inversely correlated with T-lymphocytic function in atherosclerotic coronary intimas.lld:pubmed
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pubmed-article:16460885pubmed:authorpubmed-author:NakashimaYuta...lld:pubmed
pubmed-article:16460885pubmed:authorpubmed-author:SueishiKatsuo...lld:pubmed
pubmed-article:16460885pubmed:authorpubmed-author:ItabeHiroyuki...lld:pubmed
pubmed-article:16460885pubmed:authorpubmed-author:ChenYong-Xian...lld:pubmed
pubmed-article:16460885pubmed:authorpubmed-author:SumiyoshiShin...lld:pubmed
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pubmed-article:16460885pubmed:pagination141-50lld:pubmed
pubmed-article:16460885pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:16460885pubmed:articleTitleInterleukin-10 expression is positively correlated with oxidized LDL deposition and inversely with T-lymphocyte infiltration in atherosclerotic intimas of human coronary arteries.lld:pubmed
pubmed-article:16460885pubmed:affiliationDepartment of Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.lld:pubmed
pubmed-article:16460885pubmed:publicationTypeJournal Articlelld:pubmed
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