Linked Life Data

16456192

Source:http://linkedlifedata.com/resource/pubmed/id/16456192

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pubmed-article:16456192pubmed:abstractTextWe tested the hypothesis that long-term growth hormone (GH) replacement in aged rats would preserve diastolic function and attenuate left ventricular remodeling associated with normal aging. Male Brown Norway x F344 rats were randomized to receive twice daily injections of porcine GH (200 microg/injection, subcutaneous) or saline from 24 to 30 months of age. Adult rats (6- to 9-months old) received saline injections throughout the study. Thirty-month-old, saline-treated rats exhibited low levels of insulin-like growth factor 1 (IGF-1), impaired diastolic left ventricular filling (Doppler), increased cardiac angiotensin II (Ang II), reduced plasma Ang II, and increased cardiac collagen. GH administration in old rats restored IGF-1 and diastolic indices to values comparable to those of adults. These effects were associated with reduced cardiac Ang II and attenuations in cardiac collagen. Age-related decreases in GH and IGF-1 may contribute to the decline in diastolic function of aging, in part through alterations in renin-angiotensin system-mediated ventricular remodeling.lld:pubmed
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pubmed-article:16456192pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:16456192pubmed:articleTitleGrowth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats.lld:pubmed
pubmed-article:16456192pubmed:affiliationDepartment of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1009, USA. lgroban@wfubmc.edulld:pubmed
pubmed-article:16456192pubmed:publicationTypeJournal Articlelld:pubmed
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