| pubmed-article:1645507 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1645507 | lifeskim:mentions | umls-concept:C0010823 | lld:lifeskim |
| pubmed-article:1645507 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:1645507 | lifeskim:mentions | umls-concept:C0304052 | lld:lifeskim |
| pubmed-article:1645507 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1645507 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1645507 | lifeskim:mentions | umls-concept:C0522501 | lld:lifeskim |
| pubmed-article:1645507 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1645507 | pubmed:dateCreated | 1991-7-2 | lld:pubmed |
| pubmed-article:1645507 | pubmed:abstractText | The alpha-(1-3)-D-mannose- and alpha-(1-6)-D-mannose-specific agglutinins (lectins) from Galanthus nivalis, Hippeastrum hybrid, Narcissus pseudonarcissus, and Listera ovata inhibited infection of MT-4 cells by human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus at concentrations comparable to the concentrations at which dextran sulfate (molecular weight, 5,000 [DS-5000]) inhibits these viruses (50% effective concentration, 0.2 to 0.6 microgram/ml). Unlike DS-5000, however, the plant lectins did not inhibit the replication of other enveloped viruses, except for human cytomegalovirus (50% effective concentration, 0.9 to 1.6 microgram/ml). The plant lectins suppressed syncytium formation between persistently HIV-1- or HIV-2-infected HUT-78 cells and uninfected MOLT-4 (clone 8) cells at concentrations that were 5- to 10-fold lower than that required for DS-5000. Unlike DS-5000, however, the plant lectins did not inhibit HIV-1 binding to CD4+ cells. Combination of the plant lectins with DS-5000 led to a potent synergistic inhibition of HIV-1-induced cytopathogenicity in MT-4 cells and syncytium formation between HIV-infected HUT-78 cells and MOLT-4 cells. Our data suggest that alpha-(1-3)-D- and alpha-(1-6)-D-mannose-specific plant lectins interfere with an event in the HIV replicative cycle that is subsequent to the attachment of the virions to the cells (i.e., the fusion process). | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1645507 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1645507 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1645507 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1645507 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1645507 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:1645507 | pubmed:author | pubmed-author:De ClercqEE | lld:pubmed |
| pubmed-article:1645507 | pubmed:author | pubmed-author:PeumansWW | lld:pubmed |
| pubmed-article:1645507 | pubmed:author | pubmed-author:ScholeJJ | lld:pubmed |
| pubmed-article:1645507 | pubmed:author | pubmed-author:Van DammeEE | lld:pubmed |
| pubmed-article:1645507 | pubmed:author | pubmed-author:BalzariniJJ | lld:pubmed |
| pubmed-article:1645507 | pubmed:author | pubmed-author:NeytsJJ | lld:pubmed |
| pubmed-article:1645507 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1645507 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:1645507 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1645507 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1645507 | pubmed:pagination | 410-6 | lld:pubmed |
| pubmed-article:1645507 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:meshHeading | pubmed-meshheading:1645507-... | lld:pubmed |
| pubmed-article:1645507 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1645507 | pubmed:articleTitle | Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro. | lld:pubmed |
| pubmed-article:1645507 | pubmed:affiliation | Laboratory of Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium. | lld:pubmed |
| pubmed-article:1645507 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1645507 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1645507 | lld:pubmed |
