| pubmed-article:16455048 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16455048 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16455048 | lifeskim:mentions | umls-concept:C0919506 | lld:lifeskim |
| pubmed-article:16455048 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:16455048 | lifeskim:mentions | umls-concept:C0030520 | lld:lifeskim |
| pubmed-article:16455048 | lifeskim:mentions | umls-concept:C0380603 | lld:lifeskim |
| pubmed-article:16455048 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16455048 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:16455048 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16455048 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16455048 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16455048 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16455048 | pubmed:dateCreated | 2006-2-14 | lld:pubmed |
| pubmed-article:16455048 | pubmed:abstractText | Since parathyroid hormone (PTH) increased FGF2 mRNA and protein expression in osteoblasts, and serum FGF-2 was increased in osteoporotic patients treated with PTH, we assessed whether the anabolic effect of PTH was impaired in Fgf2-/- mice. Eight-week-old Fgf2+/+ and Fgf2-/- male mice were treated with rhPTH 1-34 (80mug/kg) for 4 weeks. Micro-CT and histomorphometry demonstrated that PTH significantly increased parameters of bone formation in femurs from Fgf2+/+ mice but the changes were smaller and not significant in Fgf2-/- mice. IGF-1 was significantly reduced in serum from PTH-treated Fgf2-/- mice. DEXA analysis of femurs from Fgf2+/+, Fgf2+/-, and Fgf2-/- mice treated with rhPTH (160mug/kg) for 10 days showed that PTH significantly increased femoral BMD in Fgf2+/+ by 18%; by only 3% in Fgf2+/- mice and reduced by 3% in Fgf2-/- mice. We conclude that endogenous Fgf2 is important for maximum bone anabolic effect of PTH in mice. | lld:pubmed |
| pubmed-article:16455048 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16455048 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16455048 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16455048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16455048 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16455048 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16455048 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:16455048 | pubmed:author | pubmed-author:ItoMM | lld:pubmed |
| pubmed-article:16455048 | pubmed:author | pubmed-author:TanakaYY | lld:pubmed |
| pubmed-article:16455048 | pubmed:author | pubmed-author:OkadaYY | lld:pubmed |
| pubmed-article:16455048 | pubmed:author | pubmed-author:NakamuraTT | lld:pubmed |
| pubmed-article:16455048 | pubmed:author | pubmed-author:OkimotoNN | lld:pubmed |
| pubmed-article:16455048 | pubmed:author | pubmed-author:XianMM | lld:pubmed |
| pubmed-article:16455048 | pubmed:author | pubmed-author:HurleyM MMM | lld:pubmed |
| pubmed-article:16455048 | pubmed:author | pubmed-author:DoetschmanTT | lld:pubmed |
| pubmed-article:16455048 | pubmed:author | pubmed-author:RosenC JCJ | lld:pubmed |
| pubmed-article:16455048 | pubmed:author | pubmed-author:CoffinJ DJD | lld:pubmed |
| pubmed-article:16455048 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16455048 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:16455048 | pubmed:volume | 341 | lld:pubmed |
| pubmed-article:16455048 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16455048 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16455048 | pubmed:pagination | 989-94 | lld:pubmed |
| pubmed-article:16455048 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16455048 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16455048 | pubmed:articleTitle | Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice. | lld:pubmed |
| pubmed-article:16455048 | pubmed:affiliation | University of Connecticut Health Center, Farmington, CT, USA. Hurley@nso1.uchc.edu | lld:pubmed |
| pubmed-article:16455048 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16455048 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:14173 | entrezgene:pubmed | pubmed-article:16455048 | lld:entrezgene |
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