| pubmed-article:16452675 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C0026609 | lld:lifeskim |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C0228740 | lld:lifeskim |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C0027746 | lld:lifeskim |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16452675 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16452675 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16452675 | pubmed:dateCreated | 2006-2-2 | lld:pubmed |
| pubmed-article:16452675 | pubmed:abstractText | Adult facial motor neurons continue to express full-length TrkB tyrosine kinase receptor (TrkB.FL), the high-affinity receptor for the neurotrophins BDNF and neurotrophic factor-4/5 (NT-4/5), suggesting that they remain dependent on target-derived and locally produced neurotrophins in adulthood. Studies on the role of TrkB signaling in the adult CNS have been hampered by the early lethality of bdnf, nt-4/5, and trkB knock-out mice. We disrupted TrkB.FL signaling in adult facial motor neurons using adeno-associated viral vector-mediated overexpression of a naturally occurring dominant-negative TrkB receptor, TrkB.T1. Expression of TrkB.T1 resulted in neuronal atrophy and downregulation of NeuN (neuronal-specific nuclear protein) and ChAT expression in facial motor neurons. A subset of transduced neurons displayed signs of motor neuron degeneration that included dendritic beading and rounding of the soma at 2 months of TrkB.T1 expression. Cell counts revealed a significant reduction in motor neuron number in the facial nucleus at 4 months after onset of expression of TrkB.T1, suggesting that a proportion of TrkB.T1-expressing motor neurons became undetectable as a result of severe atrophy or was lost because of cell death. In contrast, overexpression of TrkB.FL did not result in a decrease in facial motor neuron number. Our results indicate that a subset of facial motor neurons remains dependent on TrkB ligands for the maintenance of structural and molecular characteristics in adulthood. | lld:pubmed |
| pubmed-article:16452675 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16452675 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16452675 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16452675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16452675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16452675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16452675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16452675 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16452675 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16452675 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:16452675 | pubmed:author | pubmed-author:VerhaagenJoos... | lld:pubmed |
| pubmed-article:16452675 | pubmed:author | pubmed-author:CastrénEeroE | lld:pubmed |
| pubmed-article:16452675 | pubmed:author | pubmed-author:EggersRubenR | lld:pubmed |
| pubmed-article:16452675 | pubmed:author | pubmed-author:De WitJorisJ | lld:pubmed |
| pubmed-article:16452675 | pubmed:author | pubmed-author:EversRobertR | lld:pubmed |
| pubmed-article:16452675 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16452675 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16452675 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16452675 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16452675 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16452675 | pubmed:pagination | 1516-30 | lld:pubmed |
| pubmed-article:16452675 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16452675 | pubmed:meshHeading | pubmed-meshheading:16452675... | lld:pubmed |
| pubmed-article:16452675 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16452675 | pubmed:articleTitle | Long-term adeno-associated viral vector-mediated expression of truncated TrkB in the adult rat facial nucleus results in motor neuron degeneration. | lld:pubmed |
| pubmed-article:16452675 | pubmed:affiliation | Graduate School of Neuroscience, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:16452675 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16452675 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16452675 | lld:pubmed |
