Linked Life Data

16452090

Source:http://linkedlifedata.com/resource/pubmed/id/16452090

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pubmed-article:16452090pubmed:abstractTextVertebrate craniofacial sensory organs derive from ectodermal placodes early in development. It has been suggested that all craniofacial placodes arise from a common ectodermal domain adjacent to the anterior neural plate, and a number of genes have been recently identified that mark such a 'pre-placodal' domain. However, the functional significance of this pre-placodal domain is still unclear. In the present study, we show that Fgf signaling is necessary and sufficient to directly induce some, but not all, markers of the otic placode in ectoderm taken from the pre-placodal domain. By contrast, ectoderm from outside this domain is not competent to express otic markers in response to Fgfs. Grafting naïve ectoderm into the pre-placodal domain causes upregulation of pre-placodal markers within 8 hours, together with the acquisition of competence to respond to Fgf signaling. This suggests a two-step model of craniofacial placode induction in which ectoderm first acquires pre-placodal region identity, and subsequently differentiates into particular craniofacial placodes under the influence of local inducing signals.lld:pubmed
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pubmed-article:16452090pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:16452090pubmed:year2006lld:pubmed
pubmed-article:16452090pubmed:articleTitleCompetence of cranial ectoderm to respond to Fgf signaling suggests a two-step model of otic placode induction.lld:pubmed
pubmed-article:16452090pubmed:affiliationGonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA.lld:pubmed
pubmed-article:16452090pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16452090pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:16452090pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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