| pubmed-article:16425263 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16425263 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16425263 | lifeskim:mentions | umls-concept:C0279671 | lld:lifeskim |
| pubmed-article:16425263 | lifeskim:mentions | umls-concept:C1707310 | lld:lifeskim |
| pubmed-article:16425263 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16425263 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16425263 | pubmed:dateCreated | 2006-4-3 | lld:pubmed |
| pubmed-article:16425263 | pubmed:abstractText | Tumor progression and recurrence of cervical cancer is associated with upregulation of matrix metalloproteinase 2 (MMP-2). We evaluated the location, origin and activity of MMP-2 in cervical squamous cell carcinomas in comparison with MT1-MMP (MMP-14), TIMP-2 and extracellular matrix metalloproteinase inducer (EMMPRIN). Positive immunostaining for MMP-2 in malignant cells was detected in 83% of the patients. Two patterns of tumor cell MMP-2 staining were observed: either homogenous in all tumor cells or confined to the cells neighboring the stroma (tumor-border staining pattern, TBS). Fluorescence in situ zymography showed active MMP-2 mainly around tumor nodules displaying TBS. The MMP-2 staining of TBS tumors correlated significantly with the presence of TIMP-2 and MT1-MMP, proteins involved in docking MMP-2 to the cell surface and essential for MMP-2 activation. In situ mRNA hybridization in TBS tumors demonstrated more abundant presence of MMP-2 mRNA in neighboring myofibroblasts than in the adjacent tumor cells. Moreover, the TBS MMP-2 pattern correlated with the presence of EMMPRIN (p = 0.023), suggesting that tumor cells induce MMP-2 production in nearby stromal cells. This pro-MMP-2 could subsequently be activated on tumor cells via the presence of MT1-MMP and TIMP-2. The biological relevance of this locally activated MMP-2 was underscored by the observation that only the TBS pattern of MMP-2 significantly correlated with decreased survival. In conclusion, the colocalization of EMMPRIN, MT1-MMP and TIMP-2 in human cervical carcinomas seems to be involved in a specific distribution pattern of tumor cell bound MMP-2, which is related with local proteolytic activity and therefore might be associated with worse prognosis of the patients. | lld:pubmed |
| pubmed-article:16425263 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16425263 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16425263 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16425263 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16425263 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16425263 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:16425263 | pubmed:author | pubmed-author:FleurenGert... | lld:pubmed |
| pubmed-article:16425263 | pubmed:author | pubmed-author:GorterArkoA | lld:pubmed |
| pubmed-article:16425263 | pubmed:author | pubmed-author:Mulder-Stapel... | lld:pubmed |
| pubmed-article:16425263 | pubmed:author | pubmed-author:KenterGemma... | lld:pubmed |
| pubmed-article:16425263 | pubmed:author | pubmed-author:HanemaaijerRo... | lld:pubmed |
| pubmed-article:16425263 | pubmed:author | pubmed-author:PrinsFrans... | lld:pubmed |
| pubmed-article:16425263 | pubmed:author | pubmed-author:SierCornelis... | lld:pubmed |
| pubmed-article:16425263 | pubmed:author | pubmed-author:DreefEnno JEJ | lld:pubmed |
| pubmed-article:16425263 | pubmed:author | pubmed-author:ZuidwijkKimK | lld:pubmed |
| pubmed-article:16425263 | pubmed:author | pubmed-author:ZijlmansHenry... | lld:pubmed |
| pubmed-article:16425263 | pubmed:copyrightInfo | Copyright 2006 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:16425263 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16425263 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16425263 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:16425263 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16425263 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16425263 | pubmed:pagination | 2991-8 | lld:pubmed |
| pubmed-article:16425263 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
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| pubmed-article:16425263 | pubmed:meshHeading | pubmed-meshheading:16425263... | lld:pubmed |
| pubmed-article:16425263 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16425263 | pubmed:articleTitle | EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma. | lld:pubmed |
| pubmed-article:16425263 | pubmed:affiliation | Department of Pathology, Leiden University Medical Center, The Netherlands. C.F.M.Sier@lumc.nl | lld:pubmed |
| pubmed-article:16425263 | pubmed:publicationType | Journal Article | lld:pubmed |
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