| pubmed-article:16423395 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16423395 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
| pubmed-article:16423395 | lifeskim:mentions | umls-concept:C1337107 | lld:lifeskim |
| pubmed-article:16423395 | lifeskim:mentions | umls-concept:C1416958 | lld:lifeskim |
| pubmed-article:16423395 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16423395 | pubmed:dateCreated | 2006-3-27 | lld:pubmed |
| pubmed-article:16423395 | pubmed:abstractText | Bcl-6, a major regulator of B lymphocyte function that contributes to neoplastic transformation of B cells, is expressed in activated germinal center (GC) B cells and down-regulated during terminal differentiation to plasma cells. Regulation of Bcl-6 expression is incompletely characterized. Terminal B cell differentiation is associated with down-regulation of Bcl-6, activation of Blimp-1, modulation of Myc, and specifically with the up-regulation of the Mad1 and Mad4 transcription factors, which play a critical role in cell differentiation and cell cycle regulation. Because the Mad E-box consensus binding site is present in the upstream promoter of Bcl-6, we investigated whether Bcl-6 may be under control of the Mad1 transcription factor. Anti-sense Mad1 oligonucleotides abrogated the down-regulation of Bcl-6 expression that occurred during in vitro differentiation of mouse splenic B cells induced by dextran-conjugated anti-IgD Ab and IL-5. Transduction of the WEHI 231 B cell line with retroviruses expressing Mad1 down-regulated Bcl-6 expression. Expression of the 5' upstream promoter region of Bcl-6 was down-regulated by co-expression of Mad1. Last, chromatin immunoprecipitation assays with anti-Mad1 Ab demonstrated in vivo interaction of Mad1 with the Bcl-6 promoter region. The findings suggest that Mad1 is a transcriptional repressor of Bcl-6. | lld:pubmed |
| pubmed-article:16423395 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16423395 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16423395 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16423395 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16423395 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16423395 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16423395 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16423395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16423395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16423395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16423395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16423395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16423395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16423395 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16423395 | pubmed:month | May | lld:pubmed |
| pubmed-article:16423395 | pubmed:issn | 0161-5890 | lld:pubmed |
| pubmed-article:16423395 | pubmed:author | pubmed-author:ChenLuojingL | lld:pubmed |
| pubmed-article:16423395 | pubmed:author | pubmed-author:LeeSang CSC | lld:pubmed |
| pubmed-article:16423395 | pubmed:author | pubmed-author:BottaroAndrea... | lld:pubmed |
| pubmed-article:16423395 | pubmed:author | pubmed-author:InselRichard... | lld:pubmed |
| pubmed-article:16423395 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16423395 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:16423395 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16423395 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16423395 | pubmed:pagination | 1965-71 | lld:pubmed |
| pubmed-article:16423395 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16423395 | pubmed:meshHeading | pubmed-meshheading:16423395... | lld:pubmed |
| pubmed-article:16423395 | pubmed:meshHeading | pubmed-meshheading:16423395... | lld:pubmed |
| pubmed-article:16423395 | pubmed:meshHeading | pubmed-meshheading:16423395... | lld:pubmed |
| pubmed-article:16423395 | pubmed:meshHeading | pubmed-meshheading:16423395... | lld:pubmed |
| pubmed-article:16423395 | pubmed:meshHeading | pubmed-meshheading:16423395... | lld:pubmed |
| pubmed-article:16423395 | pubmed:meshHeading | pubmed-meshheading:16423395... | lld:pubmed |
| pubmed-article:16423395 | pubmed:meshHeading | pubmed-meshheading:16423395... | lld:pubmed |
| pubmed-article:16423395 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16423395 | pubmed:articleTitle | Mad1 is a transcriptional repressor of Bcl-6. | lld:pubmed |
| pubmed-article:16423395 | pubmed:affiliation | Center for Human Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA. | lld:pubmed |
| pubmed-article:16423395 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16423395 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:17119 | entrezgene:pubmed | pubmed-article:16423395 | lld:entrezgene |
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